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Follicular lymphoma polygenic risk score is associated with increased disease risk but improved overall survival among women in a population based case-control in Los Angeles County California
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4 2020
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Source: Cancer Epidemiol. 65:101688
Details:
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Alternative Title:Cancer Epidemiol
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Description:Introduction:
Although clinical prognostic indicators exist for follicular lymphoma(FL), patient outcomes remain heterogeneous.
Material and Methods:
We evaluated the association between survival and a polygenic risk score(PRS) composed of five previously identified FL susceptibility loci(rs12195582, rs13254990, rs17749561, rs4245081, rs4938573) among women who participated in a case-control study of non-Hodgkin lymphoma in Los Angeles County between 2004-2008. Risk associations were estimated through logistic regression, calculating the odds ratios(OR) and 95% confidence intervals(95% CI). Survival was estimated under a Cox proportional hazards model and hazard ratios(HR) and 95% CI were calculated.
Results:
Among 437 non-Hispanic White controls and 100 non-Hispanic White FL patients, we confirmed a 2.6-fold increased risk of FL associated with the highest PRS tertile (95% CI:1.35-4.86). After accounting for clinical indicators, the PRS was associated with improved overall survival in non-Hispanic women (HR:0.31; 95% CI:0.10-0.96).
Conclusion:
PRS was associated with increased risk of FL, but improved overall survival.
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Pubmed ID:32092486
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Pubmed Central ID:PMC7131878
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