Follicular lymphoma polygenic risk score is associated with increased disease risk but improved overall survival among women in a population based case-control in Los Angeles County California

Details

• Alternative Title:
  Cancer Epidemiol
• Personal Author:
  Zhong, Charlie ; Chao, Chun R. ; Song, Joo Y. ; Weisenburger, Dennis D. ; Luo, Jianning ; Ding, Yuan Chun ; Neuhausen, Susan L. ; Bernstein, Leslie ; Cozen, Wendy ; Wang, Sophia S.
• Description:
  Introduction:
  
  Although clinical prognostic indicators exist for follicular lymphoma(FL), patient outcomes remain heterogeneous.
  
  Material and Methods:
  
  We evaluated the association between survival and a polygenic risk score(PRS) composed of five previously identified FL susceptibility loci(rs12195582, rs13254990, rs17749561, rs4245081, rs4938573) among women who participated in a case-control study of non-Hodgkin lymphoma in Los Angeles County between 2004-2008. Risk associations were estimated through logistic regression, calculating the odds ratios(OR) and 95% confidence intervals(95% CI). Survival was estimated under a Cox proportional hazards model and hazard ratios(HR) and 95% CI were calculated.
  
  Results:
  
  Among 437 non-Hispanic White controls and 100 non-Hispanic White FL patients, we confirmed a 2.6-fold increased risk of FL associated with the highest PRS tertile (95% CI:1.35-4.86). After accounting for clinical indicators, the PRS was associated with improved overall survival in non-Hispanic women (HR:0.31; 95% CI:0.10-0.96).
  
  Conclusion:
  
  PRS was associated with increased risk of FL, but improved overall survival.
  
  
• Subjects:
  Adult Aged Case-Control Studies Female Humans Lymphoma, Follicular Middle Aged Prognosis Risk Factors Survival Analysis
• Keywords:
  Epidemiology Genetics Non-Hodgkin Lymphoma Survival
• Source:
  Cancer Epidemiol. 65:101688
• Pubmed ID:
  32092486
• Pubmed Central ID:
  PMC7131878
• Document Type:
  Journal Article
• Funding:
  R01 CA166219/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; P01 CA017054/CA/NCI NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; R01 CA108634/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA033572/CA/NCI NIH HHSUnited States/
• Place as Subject:
  Los Angeles, CA
• Volume:
  65
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d84800e86e52fab48265fdbdada134e3b6b18743d5a71a51bac9dba6223b9956
• Download URL:
  https://stacks.cdc.gov/view/cdc/104809/cdc_104809_DS1.pdf
• File Type:
  [PDF - 106.47 KB ]