Longitudinal Trends in Per- and Polyfluoroalkyl Substances among Multiethnic Midlife Women from 1999 to 2011: the Study of Women’s Health Across the Nation

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Ding, Ning ; Harlow, Siobán D. ; Batterman, Stuart ; Mukherjee, Bhramar ; Park, Sung Kyun
• Description:
  Background:
  
  Limited information exists regarding longitudinal trends in midlife women’s exposure to per- and polyfluoroalkyl substances (PFAS). Further, little is known about how patterns of exposure differ by race/ethnicity and reproductive characteristics including parity and menopause.
  
  Objective:
  
  We aimed to examine temporal variations in serum PFAS concentrations among midlife women from the Study of Women’s Health Across the Nation.
  
  Methods:
  
  Serum concentrations of 11 PFAS homologues were measured in 75 White, Black and Chinese women with blood samples collected in 1999–2000, 2002–2003, 2005–2006, and 2009–2011. Rates of changes in PFAS concentrations were calculated assuming a first-order elimination model. Associations between PFAS concentrations and race/ethnicity, menstruation and parity were evaluated with linear mixed models, adjusting for age, body mass index and study site.
  
  Results:
  
  Serum concentrations of linear-chain perfluorooctanoic acid (n-PFOA), linear- and branched-chain perfluorooctane sulfonic acid (n-PFOS and sm-PFOS) decreased significantly (−6.0%, 95% CI: −8.3%, −3.6% per year for n-PFOA; −14.8%, 95% CI: −17.3%, −12.3% per year for n-PFOS; −16.9%, 95% CI: −19.1%, −14.6% per year for sm-PFOS); whereas perfluorononanoic acid (PFNA) increased (16.0%, 95% CI: 10.6%, 21.6% per year). Detection rates of perfluorodecanoic acid (PFDeA) and perfluoroundecanoic acid (PFUA) doubled. Temporal trends varied significantly by race/ethnicity. Chinese women tended to have consistently higher PFNA concentrations at each follow-up visit, compared with White and Black women. Serum PFHxS concentrations significantly decreased in White and Black women, but not in Chinese. Menstruating women consistently had lower concentrations. Parity was associated with lower concentrations at baseline but the differences between nulliparous and parous women became smaller over time.
  
  Conclusions:
  
  Our results suggest longitudinal declines in serum concentrations of legacy PFAS and increases in serum concentrations of emerging compounds from 1999 to 2011 in midlife women. Temporal trends in PFAS concentrations are not uniform across race/ethnicity and parity groups.
  
  
• Subjects:
  Alkanesulfonic Acids Environmental Pollutants Ethnicity Female Fluorocarbons Humans Linear Models Middle Aged Parity Pregnancy Women's Health

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• Keywords:
  Biomonitoring Buprenorphine Menstruation Methadone Midlife Women Mortality Naltrexone Per- And Polyfluoroalkyl Substances Racial/Ethnic Disparities Treatment
• Source:
  Environ Int. 135:105381
• Pubmed ID:
  31841808
• Pubmed Central ID:
  PMC7374929
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; UL1 RR024131/RR/NCRR NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; R01 ES026578/ES/NIEHS NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; R01 ES026964/ES/NIEHS NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/
• Volume:
  135
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4e97787af6d6059dc59d7956b271ebb1cea276bdf5d5b5b87004e00b40130818b9cfa76cb7ea3fd63c4238c84efe47349f7559fda06b40ce1cbeb3000602ac56
• Download URL:
  https://stacks.cdc.gov/view/cdc/90995/cdc_90995_DS1.pdf
• File Type:
  [PDF - 1.41 MB ]