Longitudinal Trends in Perfluoroalkyl and Polyfluoroalkyl Substances Among Multiethnic Midlife Women from 1999 to 2011: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Batterman S ; Ding N ; Harlow SD ; Mukherjee B ; Park SK
• Description:
  Background: Limited information exists regarding longitudinal trends in midlife women's exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS). Further, little is known about how patterns of exposure differ by race/ethnicity and reproductive characteristics including parity and menopause. Objective: We aimed to examine temporal variations in serum PFAS concentrations among midlife women from the Study of Women's Health Across the Nation. Methods: Serum concentrations of 11 PFAS homologues were measured in 75 White, Black and Chinese women with blood samples collected in 1999-2000, 2002-2003, 2005-2006, and 2009-2011. Rates of changes in PFAS concentrations were calculated assuming a first-order elimination model. Associations between PFAS concentrations and race/ethnicity, menstruation and parity were evaluated with linear mixed models, adjusting for age, body mass index and study site. Results: Serum concentrations of linear-chain perfluorooctanoic acid (n-PFOA), linear- and branched-chain perfluorooctane sulfonic acid (n-PFOS and sm-PFOS) decreased significantly (-6.0%, 95% CI: -8.3%, -3.6% per year for n-PFOA; -14.8%, 95% CI: -17.3%, -12.3% per year for n-PFOS; -16.9%, 95% CI: -19.1%, -14.6% per year for sm-PFOS); whereas perfluorononanoic acid (PFNA) increased (16.0%, 95% CI: 10.6%, 21.6% per year). Detection rates of perfluorodecanoic acid (PFDeA) and perfluoroundecanoic acid (PFUA) doubled. Temporal trends varied significantly by race/ethnicity. Chinese women tended to have consistently higher PFNA concentrations at each follow-up visit, compared with White and Black women. Serum PFHxS concentrations significantly decreased in White and Black women, but not in Chinese. Menstruating women consistently had lower concentrations. Parity was associated with lower concentrations at baseline but the differences between nulliparous and parous women became smaller over time. Conclusions: Our results suggest longitudinal declines in serum concentrations of legacy PFAS and increases in serum concentrations of emerging compounds from 1999 to 2011 in midlife women. Temporal trends in PFAS concentrations are not uniform across race/ethnicity and parity groups. [Description provided by NIOSH]
• Subjects:
  Age Factors Blood Cohort Studies Occupational Health Race Factors Safety Urogenital System Women
• Keywords:
  Age Factors Author Keywords: Perfluoroalkyl And Polyfluoroalkyl Substances Biomonitoring Blood Serum Cohort Studies Longitudinal Study Menstruation Midlife Women Parity Per- And Polyfluoroalkyl Substances PFAS Racial/Ethnic Disparities Racial Factors Reproductive System

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• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  135
• NIOSHTIC Number:
  nn:20059161
• Citation:
  Environ Int 2020 Feb; 135:105381
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan, M5541 SPH II, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029, United States
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environment International
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:171951809d4f4837a5dc46b43acb9e8fc19a665419eafadc57f9cdea725c551ddccc81046b2069964cb30a37b4baf9ede79a9e0e28c5a0241567a42a41213eb4
• Download URL:
  https://stacks.cdc.gov/view/cdc/223464/cdc_223464_DS1.pdf
• File Type:
  [PDF - 1.91 MB ]