Details:

Alternative Title:
Nat Commun
Personal Author:
Valentino, Michael D. ; McGuire, Abigail Manson ; Rosch, Jason W. ; Bispo, Paulo J. M. ; Burnham, Corinna ; ... More +
Valentino, Michael D. ; McGuire, Abigail Manson ; Rosch, Jason W. ; Bispo, Paulo J. M. ; Burnham, Corinna ; Sanfilippo, Christine M. ; Carter, Robert A. ; Zegans, Michael E. ; Beall, Bernard ; Earl, Ashlee M. ; Tuomanen, Elaine I. ; Morris, Timothy W. ; Haas, Wolfgang ; Gilmore, Michael S. Less -
Description:
Streptococcus pneumoniae, an inhabitant of the upper respiratory mucosa, causes respiratory and invasive infections as well as conjunctivitis. Strains that lack the capsule, a main virulence factor and the target of current vaccines, are often isolated from conjunctivitis cases. Here we perform a comparative genomic analysis of 271 strains of conjunctivitis-causing S. pneumoniae from 72 postal codes in the United States. We find that the vast majority of conjunctivitis strains are members of a distinct cluster of closely related unencapsulated strains. These strains possess divergent forms of pneumococcal virulence factors (such as CbpA and neuraminidases) that are not shared with other unencapsulated nasopharyngeal S. pneumoniae. They also possess putative adhesins that have not been described in encapsulated pneumococci. These findings suggest that the unencapsulated strains capable of causing conjunctivitis utilize a pathogenesis strategy substantially different from that described for S. pneumoniae at other infection sites.
Subject:
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Adhesins, Bacterial
Article
Asymptomatic Infections
Bacterial Capsules
Blotting, Western
Conjunctivitis, Bacterial
Genome, Bacterial
Humans
Multigene Family
Multilocus Sequence Typing
Phylogeny
Phylogeography
Pneumococcal Infections
Virulence Factors

Source:
Nat Commun. 5:5411
Pubmed ID:
25388376
Pubmed Central ID:
PMC4231546
Document Type:
Journal Article
Funding:
HHSN272200900018C/AI/NIAID NIH HHS/United States ; R01 EY024285/EY/NEI NIH HHS/United States ; EY007145/EY/NEI NIH HHS/United States ; AI083214/AI/NIAID NIH HHS/United States ; HHSN272200900018C/PHS HHS/United States ; ... More +
HHSN272200900018C/AI/NIAID NIH HHS/United States ; R01 EY024285/EY/NEI NIH HHS/United States ; EY007145/EY/NEI NIH HHS/United States ; AI083214/AI/NIAID NIH HHS/United States ; HHSN272200900018C/PHS HHS/United States ; P01 AI083214/AI/NIAID NIH HHS/United States ; U19 AI110818/AI/NIAID NIH HHS/United States ; T32 EY007145/EY/NEI NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:223a3c0531924721cf01d523bd23122f5d0c4e14aba4a58ba7040fcf42a0e1c0
File Type:

Supporting Files

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