Human Adenovirus Type 55 Distribution, Regional Persistence, and Genetic Variability

Hang, Jun; Kajon, Adriana E.; Graf, Paul C. F.; Berry, Irina Maljkovic; Yang, Yu; Sanborn, Mark A.; Fung, Christian K.; Adhikari, Anima; Balansay-Ames, Melinda S.; Myers, Christopher A.; Binn, Leonard N.; Jarman, Richard G.; Kuschner, Robert A.; Collins, Natalie D.

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Human Adenovirus Type 55 Distribution, Regional Persistence, and Genetic Variability

Supporting Files Public Domain

Jul 2020
By Hang, Jun ; Kajon, Adriana E. ; Graf, Paul C. F.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Hang, Jun ; Kajon, Adriana E. ; Graf, Paul C. F. ; Berry, Irina Maljkovic ; Yang, Yu ; Sanborn, Mark A. ; Fung, Christian K. ; Adhikari, Anima ; Balansay-Ames, Melinda S. ; Myers, Christopher A. ; Binn, Leonard N. ; Jarman, Richard G. ; Kuschner, Robert A. ; Collins, Natalie D.
Description:

Human adenovirus type 55 (HAdV-55) causes acute respiratory disease of variable severity and has become an emergent threat in both civilian and military populations. HAdV-55 infection is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive assessment of HAdV-55 prevalence from a global perspective. In this study, we subjected HAdV-55 isolates from various countries collected during 1969-2018 to whole-genome sequencing, genomic and proteomic comparison, and phylogenetic analyses. The results show worldwide distribution of HAdV-55; recent strains share a high degree of genomic homogeneity. Distinct strains circulated regionally for several years, suggesting persistent local transmission. Several cases of sporadic introduction of certain strains to other countries were documented. Among the identified amino acid mutations distinguishing HAdV-55 strains, some have potential impact on essential viral functions and may affect infectivity and transmission.
Subjects:
Source:

Emerg Infect Dis. 26(7):1497-1505
Pubmed ID:

32568062
Pubmed Central ID:

PMC7323512
Document Type:

Journal Article
Place as Subject:

China ; Republic of Korea
Location:

Asia
Volume:

26
Issue:

7
Download URL:

https://stacks.cdc.gov/view/cdc/90175/cdc_90175_DS1.pdf
File Type:

[PDF - 1.34 MB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:70d4fbcbaf0e20d767f3add1053a59acb7ecebc7852aa81d80658d1d8dd2510d

File Language:

English

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