Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Hang, Jun ; Kajon, Adriana E. ; Graf, Paul C. F. ; Berry, Irina Maljkovic ; Yang, Yu ; ... More +
Hang, Jun ; Kajon, Adriana E. ; Graf, Paul C. F. ; Berry, Irina Maljkovic ; Yang, Yu ; Sanborn, Mark A. ; Fung, Christian K. ; Adhikari, Anima ; Balansay-Ames, Melinda S. ; Myers, Christopher A. ; Binn, Leonard N. ; Jarman, Richard G. ; Kuschner, Robert A. ; Collins, Natalie D. Less -
Description:
Human adenovirus type 55 (HAdV-55) causes acute respiratory disease of variable severity and has become an emergent threat in both civilian and military populations. HAdV-55 infection is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive assessment of HAdV-55 prevalence from a global perspective. In this study, we subjected HAdV-55 isolates from various countries collected during 1969-2018 to whole-genome sequencing, genomic and proteomic comparison, and phylogenetic analyses. The results show worldwide distribution of HAdV-55; recent strains share a high degree of genomic homogeneity. Distinct strains circulated regionally for several years, suggesting persistent local transmission. Several cases of sporadic introduction of certain strains to other countries were documented. Among the identified amino acid mutations distinguishing HAdV-55 strains, some have potential impact on essential viral functions and may affect infectivity and transmission.
Subject:
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Adenoviruses, Human
Adenovirus Infections, Human
DNA, Viral
Humans
Phylogeny
Proteomics
Respiratory Tract Infections

Source:
Emerg Infect Dis. 26(7):1497-1505
Pubmed ID:
32568062
Pubmed Central ID:
PMC7323512
Document Type:
Journal Article
Place as Subject:
China ; Republic of Korea
China ; Republic of Korea Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:70d4fbcbaf0e20d767f3add1053a59acb7ecebc7852aa81d80658d1d8dd2510d
File Type:

Supporting Files

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