Details:

Alternative Title:
Open Forum Infect Dis
Personal Author:
Emukule, Gideon O ; Otiato, Fredrick ; Nyawanda, Bryan O ; Otieno, Nancy A ; Ochieng, Caroline A ; ... More +
Emukule, Gideon O ; Otiato, Fredrick ; Nyawanda, Bryan O ; Otieno, Nancy A ; Ochieng, Caroline A ; Ndegwa, Linus K ; Muturi, Peter ; Bigogo, Godfrey ; Verani, Jennifer R ; Muthoka, Philip M ; Hunsperger, Elizabeth ; Chaves, Sandra S Less -
Description:
Background

The impact of influenza B virus circulation in Sub-Saharan Africa is not well described.

Methods

We analyzed data from acute respiratory illness (ARI) in Kenya. We assessed clinical features and age-specific hospitalization and outpatient visit rates by person-years for influenza B/Victoria and B/Yamagata and the extent to which circulating influenza B lineages in Kenya matched the vaccine strain component of the corresponding season (based on Northern Hemisphere [October–March] and Southern Hemisphere [April–September] vaccine availability).

Results

From 2012 to 2016, influenza B represented 31% of all influenza-associated ARIs detected (annual range, 13–61%). Rates of influenza B hospitalization and outpatient visits were higher for <5 vs ≥5 years. Among <5 years, B/Victoria was associated with pneumonia hospitalization (64% vs 44%; P = .010) and in-hospital mortality (6% vs 0%; P = .042) compared with B/Yamagata, although the mean annual hospitalization rate for B/Victoria was comparable to that estimated for B/Yamagata. The 2 lineages co-circulated, and there were mismatches with available trivalent influenza vaccines in 2/9 seasons assessed.

Conclusions

Influenza B causes substantial burden in Kenya, particularly among children aged <5 years, in whom B/Victoria may be associated with increased severity. Our findings suggest a benefit from including both lineages when considering influenza vaccination in Kenya.


Subjects:
[+]
Influenza, Human Influenza B Virus
Source:
Open Forum Infect Dis. 2019; 6(10)
Pubmed ID:
31660376
Pubmed Central ID:
PMC6804754
Document Type:
Journal Article
Place as Subject:
Kenya
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d82a527b8ec921cf8693a150cb2db55c0cea7ee881b3cd22c53655bd2fef56bd
Download URL:
https://stacks.cdc.gov/view/cdc/89273/cdc_89273_DS1.pdf
File Type:

Supporting Files

• 	ofz421f0004.jpg	jpeg
  	ofz421_suppl_supplementary_figure_1.docx	docx
  	ofz421_suppl_supplementary_tables.docx	docx
  	ofz421.nxml	xml
  	ofz421f0001.gif	gif
  	ofz421f0001.jpg	jpeg
  	ofz421f0002.gif	gif
  	ofz421f0002.jpg	jpeg
  	ofz421f0003.gif	gif
  	ofz421f0003.jpg	jpeg
  	ofz421f0004.gif	gif

More +