Use of Tetanus-diphtheria (Td) vaccine in Children 4–7 years of Age: World Health Organization Consultation of Experts

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Desai, Shalini ; Scobie, Heather M. ; Cherian, Thomas ; Goodman, Tracey
• Corporate Authors:
  The Expert Group on the Use of Td vaccine in Childhood
• Description:
  For lifetime protection against diphtheria and tetanus, the World Health Organization (WHO) recommends six doses of diphtheria and tetanus containing vaccines. Td (reduced diphtheria toxoid, ≥2-5 IU) vaccines are currently licensed for ages 7 years and older, but use of Td vaccine for ages 4 years and older would have advantages for immunization programs in many low- and middle-income countries. For this reason, WHO convened an expert consultation to review the currently available evidence for the use of Td vaccine from 4 to 7 years of age which concluded: (1) no relevant biological difference in immune response in the relevant age group compared with children over 7 years of age; (2) adequate seroprotection in several studies with Td vaccine in the 4-7 age group and many studies using combination vaccines; (3) durable and protective response of at least 9-11 years duration in several longitudinal and modelling studies, (4) less reactogenicity compared with use of full-dose diphtheria vaccine, potentially improving the vaccination experience; and (5) adequate control of diphtheria in several countries using Td-containing combination vaccines in 4-7 year old children. On this basis, the experts concluded that from a programmatic perspective, Td vaccine given in ages 4-7 years, as a second booster dose in a six-dose series, would provide adequate protection against diphtheria and tetanus and recommended steps to include this change in age extension listed in the package insert.
• Subjects:
  Antibodies, Bacterial Child Child, Preschool Diphtheria Diphtheria-Tetanus-Pertussis Vaccine Diphtheria-Tetanus Vaccine Humans Immunization, Secondary Tetanus World Health Organization
• Keywords:
  Boosters Childhood Life-course Vaccine
• Source:
  Vaccine. 38(21):3800-3807
• Pubmed ID:
  31983584
• Pubmed Central ID:
  PMC7286697
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/Intramural CDC HHSUnited States/
• Volume:
  38
• Issue:
  21
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:137d19d66f44ddfaf812d9a9937095f52142f4f8037f2f6160efb35fd4ffb08515ef0b2e0238a71e2108b05653391d00829f785efda0dd4dfb91dded7a8d3bef
• Download URL:
  https://stacks.cdc.gov/view/cdc/89161/cdc_89161_DS1.pdf
• File Type:
  [PDF - 125.81 KB ]