Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

Kain, Taylor; Lindsay, Patrick J.; Adhikari, Neill K.J.; Arabi, Yaseen M.; Van Kerkhove, Maria D.; Fowler, Robert A.

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Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

June 17 2020
By Kain, Taylor ; Lindsay, Patrick J. ; Adhikari, Neill K.J. ; ...
Source: Emerg Infect Dis. 26(6):1102-1112

[PDF-604.95 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Kain, Taylor ; Lindsay, Patrick J. ; Adhikari, Neill K.J. ; Arabi, Yaseen M. ; Van Kerkhove, Maria D. ; ... More +

Kain, Taylor ; Lindsay, Patrick J. ; Adhikari, Neill K.J. ; Arabi, Yaseen M. ; Van Kerkhove, Maria D. ; Fowler, Robert A. Less -
Description:

Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.
Subjects:

[+]

Antiviral Agents Coronavirus Infections Humans Middle East Respiratory Syndrome Coronavirus
Source:

Emerg Infect Dis. 26(6):1102-1112
Pubmed ID:

32213260
Pubmed Central ID:

PMC7258456
Document Type:

Journal Article
Volume:

26
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:439b9d286c446913a7d15237c0d0e0525f374765dbddee3a90451cceac8715da
Download URL:

https://stacks.cdc.gov/view/cdc/88892/cdc_88892_DS1.pdf
File Type:

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