Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bonnin, Rémy A. ; Jousset, Agnès B. ; Chiarelli, Adriana ; Emeraud, Cécile ; Glaser, Philippe ; ... More +
Bonnin, Rémy A. ; Jousset, Agnès B. ; Chiarelli, Adriana ; Emeraud, Cécile ; Glaser, Philippe ; Naas, Thierry ; Dortet, Laurent Less -
Description:
The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of bla| genes. The bla| genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone.
Subject:
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Antimicrobial Resistance Bacteria Bacterial Infections Carbapenemase Emergence Of New Non–Clonal Group 258 High-Risk Clones Among Klebsiella Pneumoniae Carbapenemase–Producing K. Pneumoniae Isolates, France Epidemiology France Klebsiella Pneumoniae Kpc Nosocomial Infections Research St147 St307 Whole-Genome Sequencing
Source:
Emerg Infect Dis. 26(6):1212-1220
Pubmed ID:
32441629
Pubmed Central ID:
PMC7258464
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:2ceeaed9273df94ca1e96e42cf95565fffab53957e543c73841ca69baa7d9b45
Download URL:
https://stacks.cdc.gov/view/cdc/88884/cdc_88884_DS1.pdf
File Type:

Supporting Files

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  	19-1517-Techapp-s1.xlsx	xlsx
  	19-1517-Techapp-s2.pdf	pdf

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