Emergence of New Non–Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae Isolates, France

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bonnin, Rémy A. ; Jousset, Agnès B. ; Chiarelli, Adriana ; Emeraud, Cécile ; Glaser, Philippe ; Naas, Thierry ; Dortet, Laurent
• Description:
  The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of bla| genes. The bla| genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone.
• Subjects:
  Antimicrobial Resistance Bacteria Bacterial Infections Carbapenemase Emergence Of New Non–Clonal Group 258 High-Risk Clones Among Klebsiella Pneumoniae Carbapenemase–Producing K. Pneumoniae Isolates, France Epidemiology France Klebsiella Pneumoniae Kpc Nosocomial Infections Research St147 St307 Whole-Genome Sequencing

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• Source:
  Emerg Infect Dis. 26(6):1212-1220
• Pubmed ID:
  32441629
• Pubmed Central ID:
  PMC7258464
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2ceeaed9273df94ca1e96e42cf95565fffab53957e543c73841ca69baa7d9b45
• Download URL:
  https://stacks.cdc.gov/view/cdc/88884/cdc_88884_DS1.pdf
• File Type:
  [PDF - 2.15 MB ]