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No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
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Jun 2020
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Source: Emerg Infect Dis. 26(6):1300-1303
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Alternative Title:Emerg Infect Dis
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Description:We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.
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Pubmed ID:32441626
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Pubmed Central ID:PMC7258451
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