No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Boyle, Aileen ; Plinston, Chris ; Laing, Fraser ; Mackenzie, Graeme ; Will, Robert G. ; Manson, Jean C. ; Diack, Abigail B.
• Description:
  We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.
• Subjects:
  Bovine Spongiform Encephalopathy Dispatch No Adaptation Of The Prion Strain In A Heterozygous Case Of Variant Creutzfeldt-Jakob Disease Prions And Related Diseases Strain Transmissible Spongiform Encephalopathy Variant Creutzfeldt-Jakob Disease Vcjd Zoonoses
• Source:
  Emerg Infect Dis. 26(6):1300-1303
• Pubmed ID:
  32441626
• Pubmed Central ID:
  PMC7258451
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ad7c30edd0e5ce7d100e11bea0d3234a21fd0c259c572ab177e9271b20e4e6ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/88875/cdc_88875_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]