Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–20171

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cook, Aliza ; Janse, Sarah ; Watson, Joshua R. ; Erdem, Guliz
• Description:
  Data are limited on the incidence and management of streptococcal toxic shock syndrome (TSS) and nonstreptococcal TSS in children. We aimed to define the clinical patterns of TSS at Nationwide Children's Hospital in Ohio as they relate to published criteria, diagnostic decisions, and treatment options. Through retrospective chart reviews, we identified 58 patients with TSS (27 streptococcal, 31 nonstreptococcal) during January 2010-September 2017. We observed clinical and laboratory findings that are not part of TSS criteria, such as pyuria in streptococcal TSS (50% of patients) and pulmonary involvement (85%) and coagulopathy (92%) in nonstreptococcal TSS patients. Recommended treatment with clindamycin and intravenous immunoglobulin was delayed in streptococcal TSS patients without rash (3.37 days vs. 0.87 days in patients with rash), leading to prolonged hospitalization and complications. Incorporation of additional TSS signs and symptoms would be helpful in TSS diagnosis and management.
• Subjects:
  Child Humans Retrospective Studies Shock, Septic Streptococcal Infections Streptococcus Pyogenes
• Source:
  Emerg Infect Dis. 26(6):1077-1083
• Pubmed ID:
  32442091
• Pubmed Central ID:
  PMC7258457
• Document Type:
  Journal Article
• Place as Subject:
  Ohio
• Volume:
  26
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6e54779f1f486b998cc73e3e706c029747b9f78d0fa80dd07140b5ffb746f62c
• Download URL:
  https://stacks.cdc.gov/view/cdc/88869/cdc_88869_DS1.pdf
• File Type:
  [PDF - 2.48 MB ]