Medroxyprogesterone acetate concentrations among HIV-infected depot-medroxyprogesterone acetate users receiving antiretroviral therapy in Lilongwe, Malawi☆,☆☆

Details

• Alternative Title:
  Contraception
• Personal Author:
  Zia, Yasaman ; Tang, Jennifer H. ; Chinula, Lameck ; Tegha, Gerald ; Stanczyk, Frank Z. ; Kourtis, Athena P.
• Description:
  Objective:
  
  To compare medroxyprogesterone acetate (MPA) concentrations between HIV-positive women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable.
  
  Study design:
  
  Secondary analysis of 28 HIV-positive women on non-nucleoside reverse transcriptase inhibitor-containing ART regimens and 10 HIV-negative women randomized to initiate DMPA in a clinical trial of progestin contraception in Malawi.
  
  Results:
  
  MPA concentrations were significantly lower among HIV-positive women on ART, compared with HIV-negative women, at week 4 and week 13 (p=.03 for both), but not at day 3 or week 26 post-DMPA initiation.
  
  Conclusions:
  
  Antiretroviral medications may affect MPA metabolism in HIV-positive African women.
  
  
• Subjects:
  Adult Anti-HIV Agents Contraception Contraceptive Agents, Female Delayed-Action Preparations Female HIV Infections Humans Malawi Medroxyprogesterone Acetate Progestins Treatment Outcome Young Adult

  More +
• Keywords:
  Africa Antiretroviral Therapy Depot Medroxyprogesterone Acetate HIV
• Source:
  Contraception. 100(5):402-405
• Pubmed ID:
  31374188
• Pubmed Central ID:
  PMC7245365
• Document Type:
  Journal Article
• Funding:
  K01 TW009657/TW/FIC NIH HHSUnited States/ ; U36 OE000002/OE/OSELS CDC HHSUnited States/
• Volume:
  100
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c83e7c8c6006f06cdabe0d81831c16d6629cc3ed6b369b052f5672cca4c29fbf
• Download URL:
  https://stacks.cdc.gov/view/cdc/88391/cdc_88391_DS1.pdf
• File Type:
  [PDF - 539.73 KB ]