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Medroxyprogesterone acetate concentrations among HIV-infected depot-medroxyprogesterone acetate users receiving antiretroviral therapy in Lilongwe, Malawi☆,☆☆
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11 2019
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Source: Contraception. 100(5):402-405
Details:
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Alternative Title:Contraception
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Personal Author:
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Description:Objective:
To compare medroxyprogesterone acetate (MPA) concentrations between HIV-positive women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable.
Study design:
Secondary analysis of 28 HIV-positive women on non-nucleoside reverse transcriptase inhibitor-containing ART regimens and 10 HIV-negative women randomized to initiate DMPA in a clinical trial of progestin contraception in Malawi.
Results:
MPA concentrations were significantly lower among HIV-positive women on ART, compared with HIV-negative women, at week 4 and week 13 (p=.03 for both), but not at day 3 or week 26 post-DMPA initiation.
Conclusions:
Antiretroviral medications may affect MPA metabolism in HIV-positive African women.
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Source:
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Pubmed ID:31374188
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Pubmed Central ID:PMC7245365
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Document Type:
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Funding:
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Volume:100
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Issue:5
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