Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

Lo, Michael K; Spengler, Jessica R; Krumpe, Lauren R H; Welch, Stephen R; Chattopadhyay, Anasuya; Harmon, Jessica R; Coleman-McCray, JoAnn D; Scholte, Florine E M; Hotard, Anne L; Fuqua, Joshua L; Rose, John K; Nichol, Stuart T; Palmer, Kenneth E; O’Keefe, Barry R; Spiropoulou, Christina F

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Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

May 11 2020
By Lo, Michael K ; Spengler, Jessica R ; Krumpe, Lauren R H ; ...
Source: J Infect Dis. 2020; 221(Suppl 4):S480-S492

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Alternative Title:

J Infect Dis
Personal Author:

Lo, Michael K ; Spengler, Jessica R ; Krumpe, Lauren R H ; Welch, Stephen R ; Chattopadhyay, Anasuya ; ... More +

Lo, Michael K ; Spengler, Jessica R ; Krumpe, Lauren R H ; Welch, Stephen R ; Chattopadhyay, Anasuya ; Harmon, Jessica R ; Coleman-McCray, JoAnn D ; Scholte, Florine E M ; Hotard, Anne L ; Fuqua, Joshua L ; Rose, John K ; Nichol, Stuart T ; Palmer, Kenneth E ; O’Keefe, Barry R ; Spiropoulou, Christina F Less -
Description:

Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved therapeutic for human use against NiV infection. Griffithsin (GRFT) is high-mannose oligosaccharide binding lectin that has shown in vivo broad-spectrum activity against viruses, including severe acute respiratory syndrome coronavirus, human immunodeficiency virus 1, hepatitis C virus, and Japanese encephalitis virus. In this study, we evaluated the in vitro antiviral activities of GRFT and its synthetic trimeric tandemer (3mG) against NiV and other viruses from 4 virus families. The 3mG had comparatively greater potency than GRFT against NiV due to its enhanced ability to block NiV glycoprotein-induced syncytia formation. Our initial in vivo prophylactic evaluation of an oxidation-resistant GRFT (Q-GRFT) showed significant protection against lethal NiV challenge in Syrian golden hamsters. Our results warrant further development of Q-GRFT and 3mG as potential NiV therapeutics.
Subjects:

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AcademicSubjects/MED00860 Antiviral Griffithsin Hamster Nipah Supplement Articles Therapeutic
Source:

J Infect Dis. 2020; 221(Suppl 4):S480-S492
Pubmed ID:

32037447
Pubmed Central ID:

PMC7199786
Document Type:

Journal Article
Volume:

221
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:c680660cd6d4ec448e8d167fbd9e715d94f8054ccf0dc33a647064775820014a
Download URL:

https://stacks.cdc.gov/view/cdc/87733/cdc_87733_DS1.pdf
File Type:

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