Rhizopus microsporus Infections Associated with Surgical Procedures, Argentina, 2006–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bowers, Jolene R. ; Monroy-Nieto, Juan ; Gade, Lalitha ; Travis, Jason ; Refojo, Nicolás ; Abrantes, Ruben ; Santander, Jorge ; French, Chris ; Dignani, María Cecilia ; Hevia, Alejandra Ines ; Roe, Chandler C. ; Lemmer, Darrin ; Lockhart, Shawn R. ; Chiller, Tom ; Litvintseva, Anastasia P. ; Clara, Liliana ; Engelthaler, David M.
• Description:
  Rhizopus spp. fungi are ubiquitous in the environment and a rare but substantial cause of infection in immunosuppressed persons and surgery patients. During 2005-2017, an abnormally high number of Rhizopus infections in surgery patients, with no apparent epidemiologic links, were reported in Argentina. To determine the likelihood of a common source of the cluster, we performed whole-genome sequencing on samples collected during 2006-2014. Most isolates were separated by >60 single-nucleotide polymorphisms, and we found no evidence for recombination or nonneutral mutation accumulation; these findings do not support common source or patient-to-patient transmission. Assembled genomes of most isolates were ≈25 Mbp, and multiple isolates had substantially larger assembled genomes (43-51 Mbp), indicative of infections with strain types that underwent genome expansion. Whole-genome sequencing has become an essential tool for studying epidemiology of fungal infections. Less discriminatory techniques may miss true relationships, possibly resulting in inappropriate attribution of point source.
• Subjects:
  Humans Mucormycosis Rhizopus
• Source:
  Emerg Infect Dis. 26(5):937-944
• Pubmed ID:
  32310081
• Pubmed Central ID:
  PMC7181922
• Document Type:
  Journal Article
• Place as Subject:
  Argentina
• Volume:
  26
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:60969503665949e5bee3f204be68385930a912168265b48d37532245048d8156
• Download URL:
  https://stacks.cdc.gov/view/cdc/87665/cdc_87665_DS1.pdf
• File Type:
  [PDF - 1.25 MB ]