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Clinical and Mycologic Characteristics of Emerging Mucormycosis Agent Rhizopus homothallicus

Supporting Files Public Domain
File Language:
English


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  • Alternative Title:
    Emerg Infect Dis
  • Personal Author:
    Rudramurthy, Shivaprakash M. ; Singh, Shreya ; Kanaujia, Rimjhim ; Chaudhary, Hansraj ; Muthu, Valliappan ; Panda, Naresh ; Pandey, Abhishek ; Thakur, Sheetal ; Kaur, Harsimran ; Ghosh, Anup ; Agarwal, Ritesh ; Chakrabarti, Arunaloke
  • Description:
    We retrospectively reviewed consecutive cases of mucormycosis reported from a tertiary-care center in India to determine the clinical and mycologic characteristics of emerging Rhizopus homothallicus fungus. The objectives were ascertaining the proportion of R. homothallicus infection and the 30-day mortality rate in rhino-orbital mucormycosis attributable to R. homothallicus compared with R. arrhizus. R. homothallicus accounted for 43 (6.8%) of the 631 cases of mucormycosis. R. homothallicus infection was independently associated with better survival (odds ratio OR 0.08 95% CI 0.02-0.36; p = 0.001) than for R. arrhizus infection (4/41 9.8% vs. 104/266 39.1%) after adjusting for age, intracranial involvement, and surgery. We also performed antifungal-susceptibility testing, which indicated a low range of MICs for R. homothallicus against the commonly used antifungals (amphotericin B 0.03-16, itraconazole 0.03-16, posaconazole 0.03-8, and isavuconazole 0.03-16). 18S gene sequencing and amplified length polymorphism analysis revealed distinct clustering of R. homothallicus.
  • Subjects:
  • Source:
    Emerg Infect Dis. 2023; 29(7):1313-1322
  • Pubmed ID:
    37347535
  • Pubmed Central ID:
    PMC10310386
  • Document Type:
    Journal Article
  • Place as Subject:
    India
  • Volume:
    29
  • Issue:
    7
  • Download URL:
    https://stacks.cdc.gov/view/cdc/130800/cdc_130800_DS1.pdf
  • File Type:
    Filetype[PDF - 3.79 MB]
  • Collection(s):
    Emerging Infectious Diseases
  • Main Document Checksum:
    urn:sha256:f08a7fef9102afcab73bc9f4b7665c9a54113102382c655e09cd97f7b48ab839
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