Clinical and Mycologic Characteristics of Emerging Mucormycosis Agent Rhizopus homothallicus

Rudramurthy, Shivaprakash M.; Singh, Shreya; Kanaujia, Rimjhim; Chaudhary, Hansraj; Muthu, Valliappan; Panda, Naresh; Pandey, Abhishek; Thakur, Sheetal; Kaur, Harsimran; Ghosh, Anup; Agarwal, Ritesh; Chakrabarti, Arunaloke

doi:10.3201/eid2907.221491

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Clinical and Mycologic Characteristics of Emerging Mucormycosis Agent Rhizopus homothallicus

7 2023
By Rudramurthy, Shivaprakash M. ; Singh, Shreya ; Kanaujia, Rimjhim ; ...
http://dx.doi.org/10.3201/eid2907.221491
Source: Emerg Infect Dis. 2023; 29(7):1313-1322

[PDF-3.79 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Rudramurthy, Shivaprakash M. ; Singh, Shreya ; Kanaujia, Rimjhim ; Chaudhary, Hansraj ; Muthu, Valliappan ; ... More +

Rudramurthy, Shivaprakash M. ; Singh, Shreya ; Kanaujia, Rimjhim ; Chaudhary, Hansraj ; Muthu, Valliappan ; Panda, Naresh ; Pandey, Abhishek ; Thakur, Sheetal ; Kaur, Harsimran ; Ghosh, Anup ; Agarwal, Ritesh ; Chakrabarti, Arunaloke Less -
Description:

We retrospectively reviewed consecutive cases of mucormycosis reported from a tertiary-care center in India to determine the clinical and mycologic characteristics of emerging Rhizopus homothallicus fungus. The objectives were ascertaining the proportion of R. homothallicus infection and the 30-day mortality rate in rhino-orbital mucormycosis attributable to R. homothallicus compared with R. arrhizus. R. homothallicus accounted for 43 (6.8%) of the 631 cases of mucormycosis. R. homothallicus infection was independently associated with better survival (odds ratio [OR] 0.08 [95% CI 0.02-0.36]; p = 0.001) than for R. arrhizus infection (4/41 [9.8%] vs. 104/266 [39.1%]) after adjusting for age, intracranial involvement, and surgery. We also performed antifungal-susceptibility testing, which indicated a low range of MICs for R. homothallicus against the commonly used antifungals (amphotericin B [0.03-16], itraconazole [0.03-16], posaconazole [0.03-8], and isavuconazole [0.03-16]). 18S gene sequencing and amplified length polymorphism analysis revealed distinct clustering of R. homothallicus.
Subjects:

[+]

Antifungal Agents Humans Mucorales Mucormycosis Retrospective Studies Rhizopus
Source:

Emerg Infect Dis. 2023; 29(7):1313-1322
Pubmed ID:

37347535
Pubmed Central ID:

PMC10310386
Document Type:

Journal Article
Place as Subject:

India
Volume:

29
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:f08a7fef9102afcab73bc9f4b7665c9a54113102382c655e09cd97f7b48ab839
Download URL:

https://stacks.cdc.gov/view/cdc/130800/cdc_130800_DS1.pdf
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