Elevated Prevalence of Moderate-to-Severe Hepatic Steatosis in World Trade Center General Responder Cohort in a Program of CT Lung Screening

Details

• Alternative Title:
  Clin Imaging
• Personal Author:
  Chen, Xiangmeng ; Ma, Teng ; Yip, Rowena ; Perumalswami, Ponni V. ; Branch, Andrea D. ; Lewis, Sara ; Crane, Michael ; Yankelevitz, David F. ; Henschke, Claudia I.
• Description:
  Background and aims
  
  To determine the prevalence of moderate-to-severe hepatic steatosis (HS) and associated risk factors in members of the World Trade Center (WTC) General Responder Cohort (GRC) who qualify for low-dose non-contrast computed tomography for lung cancer screening and compare them to non-WTC participants in the same screening program.
  
  Methods
  
  All participants gave written informed consent before participating in this IRB-approved study. Clinical variables and laboratory values were recorded. Hepatic attenuation measurement (Hounsfield unit; HU) was measured on low-dose computed tomography (LDCT) and a threshold attenuation value <40HU indicated moderate-to-severe HS. Bivariate and multivariable linear and logistic regression analyses were performed. Propensity scores (PS) were calculated and inverse probability weighting (IPW) was used to adjust for potential confounders when comparing the WTC with non-WTC participants.
  
  Results
  
  The prevalence of moderate-to-severe HS was 16.2% among 154 WTC participants compared to 5.3% among 170 non-WTC participants. In WTC members, moderate-to-severe HS was associated with higher BMI, higher laboratory liver function tests, and former smoking status. Using PS analysis and IPW to account for potential confounders, the odds ratio for moderate-to-severe HS was 3.4-fold higher (95% confidence interval: 1.7–6.7) in the WTC participants compared with non-WTC participants. Moderate-to-severe HS was also associated with higher BMI and former smoker status.
  
  Conclusion
  
  Prevalence of moderate-to-severe HS was more than 3-fold higher in the WTC-GRC group than in other participants.
  
  
• Subjects:
  Airborne Particulate Matter Article CT Screening Liver Attenuation Liver Disease
• Source:
  Clin Imaging. 60(2):237-243
• Pubmed ID:
  31945662
• Pubmed Central ID:
  PMC7191946
• Document Type:
  Journal Article
• Funding:
  U01 OH011489/OH/NIOSH CDC HHS/United States
• Volume:
  60
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1ff5a37cd66420c95d3b5de8cc6b2c377461ba43a58e98473bc74b14efd5fd18
• Download URL:
  https://stacks.cdc.gov/view/cdc/87456/cdc_87456_DS1.pdf
• File Type:
  [PDF - 521.95 KB ]