Elevated Prevalence of Moderate-to-Severe Hepatic Steatosis in World Trade Center General Responder Cohort in a Program of CT Lung Screening

Details

• Personal Author:
  Branch AD ; Chen X ; Crane M ; Henschke CI ; Lewis S ; Ma T ; Perumalswami PV ; Yankelevitz DF ; Yip R
• Description:
  Background and aims: To determine the prevalence of moderate-to-severe hepatic steatosis (HS) and associated risk factors in members of the World Trade Center (WTC) General Responder Cohort (GRC) who qualify for low-dose non-contrast computed tomography for lung cancer screening and compare them to non-WTC participants in the same screening program. Methods: All participants gave written informed consent before participating in this IRB-approved study. Clinical variables and laboratory values were recorded. Hepatic attenuation measurement (Hounsfield unit; HU) was measured on low-dose computed tomography (LDCT) and a threshold attenuation value <40HU indicated moderate-to-severe HS. Bivariate and multivariable linear and logistic regression analyses were performed. Propensity scores (PS) were calculated and inverse probability weighting (IPW) was used to adjust for potential confounders when comparing the WTC with non-WTC participants. Results: The prevalence of moderate-to-severe HS was 16.2% among 154 WTC participants compared to 5.3% among 170 non-WTC participants. In WTC members, moderate-to-severe HS was associated with higher BMI, higher laboratory liver function tests, and former smoking status. Using PS analysis and IPW to account for potential confounders, the odds ratio for moderate-to-severe HS was 3.4-fold higher (95% confidence interval: 1.7-6.7) in the WTC participants compared with non-WTC participants. Moderate-to-severe HS was also associated with higher BMI and former smoker status. Conclusion: Prevalence of moderate-to-severe HS was >3-fold higher in the WTC-GRC group than in other participants. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Emergency Responders Lung Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Airborne Particulate Matter Author Keywords: Liver Attenuation Clinical Tests Cohort Studies CT Screening First Responders Imaging Techniques Liver Disease Liver Function Lung Function Medical Screening World Trade Center WTC

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• ISSN:
  0899-7071
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  237-243
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20059133
• Citation:
  Clin Imaging 2020 Apr; 60(2):237-243
• Contact Point Address:
  Claudia I. Henschke, Department of Radiology, Box 1234, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place, New York, NY 10029, United States
• Email:
  claudia.henshke@mountsinai.org
• Federal Fiscal Year:
  2020
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Clinical Imaging
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4887e1d3e3a8986d3c99f54574d3e7f684b33f1b35530468b7d93023ef2c2ea10740e50fffbfc319294673c75334bfe8fcb744849aacdc53c81509019a6bd4ab
• Download URL:
  https://stacks.cdc.gov/view/cdc/223444/cdc_223444_DS1.pdf
• File Type:
  [PDF - 590.19 KB ]