Dose-Response Relationship Between World Trade Center Dust Exposure and Hepatic Steatosis

Details

• Personal Author:
  Branch AD ; Crane M ; Henschke CI ; Jirapatnakul A ; Lewis S ; Yankelevitz DF ; Yip R
• Description:
  Background: The World Trade Center (WTC) attack exposed thousands of workers to toxic chemicals that have been linked to liver diseases and cancers. This study examined the relationship between the intensity of WTC dust exposure and the risk of hepatic steatosis in the WTC General Responders Cohort (GRC). Methods: All low-dose computed tomography (CT) scans of the chest performed on the WTC GRC between September 11, 2001 and December 31, 2018, collected as part of the World Trade Center Health Program, were reviewed. WTC dust exposure was categorized into five groups based on WTC arrival time. CT liver density was estimated using an automated algorithm, statistics-based liver density estimation from imaging. The relationship between the intensity of WTC dust exposure and the risk of hepatic steatosis was examined using univariate and multivariable regression analyses. Results: Of the 1788 WTC responders, 258 (14.4%) had liver attenuation less than 40 Hounsfield units (HU < 40) on their earliest CT. Median time after September 11, 2001 and the earliest available CT was 11.3 years (interquartile range: 8.0-14.9 years). Prevalence of liver attenuation less than 40 HU was 17.0% for arrivals on September 11, 2001, 16.0% for arrivals on (September 12, 2001 or September 13, 2001), 10.9% for arrivals on September 14-30, 2001, and 9.0% for arrivals on January 10, 2001 or later (p = 0.0015). A statistically significant trend of increasing liver steatosis was observed with earlier arrival times (p < 0.0001). WTC arrival time remained a significant independent factor for decreased liver attenuation after controlling for other covariates. Conclusions: Early arrival at the WTC site was significantly associated with increasing hepatic steatosis. [Description provided by NIOSH]
• Subjects:
  Dust Emergency Responders Neoplasms Occupational Health Particulate Matter Safety September 11 Terrorist Attacks
• Keywords:
  Airborne Particulate Matter Author Keywords: Adverse Effects Automated Measurement Cancer Chemicals Computed Tomography Dust Exposure Dusts Fatty Liver First Responders Liver Density Measurement Liver Disease Long Term Consequences Particulate Dust Particulates Regression Analysis Rescue Workers Screening Statistical Analysis Toxic Effects World Trade Center WTC

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  10
• NIOSHTIC Number:
  nn:20063189
• Citation:
  Am J Ind Med 2021 Oct; 64(10):837-844
• Contact Point Address:
  Claudia I. Henschke PhD, MD, Department of Radiology, Icahn School of Medicine at Mount Sinai, Box 1234, One Gustave L. Levy Pl New York, NY 10029
• Email:
  claudia.henschke@mountsinai.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2266f5664c8e484574492b972c0eae4ed35fa4d0f34414cedc6fdda95bf9cb350dc4bfcad2e31f5d66a1a2a3625556ebd4c05d7069070208ae1a178b21764fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/226294/cdc_226294_DS1.pdf
• File Type:
  [PDF - 534.81 KB ]