CASE-CONTROL STUDY OF PARESTHESIA AMONG WORLD TRADE CENTER-EXPOSED COMMUNITY MEMBERS

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Marmor, Michael ; Thawani, Sujata ; Cotrina, Maria Luisa ; Shao, Yongzhao ; Wong, Ericka S. ; Stecker, Mark M. ; Wang, Bin ; Allen, Alexander ; Wilkenfeld, Marc ; Vinik, Etta J. ; Vinik, Aaron I. ; Reibman, Joan
• Description:
  Objective:
  
  To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities or neurotoxin exposures.
  
  Methods:
  
  Case-control study comparing WTC-exposed paresthesia cases with “clinic controls” (WTC-exposed subjects without paresthesias), and “community controls” (WTC-unexposed persons).
  
  Results:
  
  Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were <0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups.
  
  Conclusions:
  
  Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies.
  
  
• Subjects:
  Adult Case-Control Studies Disasters Dust Female Humans Male Middle Aged New York City Occupational Exposure Paresthesia Risk Factors September 11 Terrorist Attacks

  More +
• Keywords:
  Buprenorphine Electrodiagnostic Neurologic Measurements Methadone Mortality Naltrexone Neuropathic Symptoms Peripheral Neuropathy Small Nerve Fiber Density Treatment
• Source:
  J Occup Environ Med. 62(4):307-316
• Pubmed ID:
  32049876
• Pubmed Central ID:
  PMC7113112
• Document Type:
  Journal Article
• Funding:
  UL1 TR001445/TR/NCATS NIH HHSUnited States/ ; R01 EY015520/EY/NEI NIH HHSUnited States/ ; P30 ES000260/ES/NIEHS NIH HHSUnited States/ ; U01 OH011305/OH/NIOSH CDC HHSUnited States/ ; U01 OH010394/OH/NIOSH CDC HHSUnited States/ ; U01 OH010395/OH/NIOSH CDC HHSUnited States/
• Volume:
  62
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6b6f0876632ee6635b01f813e0a9ec618ac590857278f70f2de02fa41c0883a31e72769bb849cda9c910e6abedd10d355e4ea4d3872ea15b3095e68a1fa0ea78
• Download URL:
  https://stacks.cdc.gov/view/cdc/86395/cdc_86395_DS1.pdf
• File Type:
  [PDF - 686.54 KB ]