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CASE-CONTROL STUDY OF PARESTHESIA AMONG WORLD TRADE CENTER-EXPOSED COMMUNITY MEMBERS
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4 2020
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Source: J Occup Environ Med. 62(4):307-316
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Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective:
To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities or neurotoxin exposures.
Methods:
Case-control study comparing WTC-exposed paresthesia cases with “clinic controls” (WTC-exposed subjects without paresthesias), and “community controls” (WTC-unexposed persons).
Results:
Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were <0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups.
Conclusions:
Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies.
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Pubmed ID:32049876
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Pubmed Central ID:PMC7113112
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