Case-Control Study of Paresthesia Among World Trade Center-Exposed Community Members

Details

• Personal Author:
  Allen A ; Cotrina ML ; Marmor M ; Reibman J ; Shao Y ; Stecker MM ; Thawani S ; Vinik AI ; Vinik EJ ; Wang B ; Wilkenfeld M ; Wong ES
• Description:
  Objective: To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities, or neurotoxin exposures. Methods: Case-control study comparing WTC-exposed paresthesia cases with "clinic controls" (WTC-exposed subjects without paresthesias), and "community controls" (WTC-unexposed persons). Results: Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were less than 0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups. Conclusions: Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies. [Description provided by NIOSH]
• Subjects:
  Diagnosis Environmental Exposure Hazardous Substances Health Care Facilities Workforce And Services Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Author Keywords: Electrodiagnostic Diagnostic Techniques Disaster Clean-up Environmental Exposure Etiology Exposure Assessment Hazardous Materials Hazardous Waste Cleanup Humans Medical Examinations Medical Monitoring Medical Screening Metabolic Disorders Nerve Fibers Nerve Function Neurological Disorders Neurologic Measurements Neuromotor System Neuropathic Symptoms Neuropathy Neurotoxins Paresthesia Peripheral Nervous System Peripheral Neuropathy Risk Factors Small Nerve Fiber Density World Trade Center WTC

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 9 ; Pennsylvania ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  307-316
• Volume:
  62
• Issue:
  4
• NIOSHTIC Number:
  nn:20059237
• Citation:
  J Occup Environ Med 2020 Apr; 62(4):307-316
• Contact Point Address:
  Michael Marmor, PhD, Department of Population Health, 180 Madison Avenue, Room 9-53, New York, NY 10016
• Email:
  Michael.Marmor@nyulangone.org
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0432e2853e0e035ae25584a0ba35a9587e053b207aa554062032f5b8d50fe585c85e5348878f118e7cf99ee4411ecc15786502e61f1cda5094e4ed70f6e1f73
• Download URL:
  https://stacks.cdc.gov/view/cdc/223522/cdc_223522_DS1.pdf
• File Type:
  [PDF - 235.24 KB ]