Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China

Details

• Alternative Title:
  J Trace Elem Med Biol
• Personal Author:
  Hasan, Zainab ; Rolle-McFarland, Danelle ; Liu, Yingzi ; Zhou, Jieqiong ; Mostafaei, Farshad ; Li, Yan ; Fan, Qiyuan ; Zhou, Yuanzhong ; Zheng, Wei ; Nie, Linda H. ; Wells, Ellen M.
• Description:
  Objectives
  
  Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).
  
  Methods
  
  We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and education compared fingernail Al and Al CEIs with bone Al.
  
  Results
  
  Median (interquartile range (IQR)) Al measurements were: 15 μg/g dry bone (IQR=28) for bone Al; 34.9 μg/g (43.3) for fingernail; and 24 (20) for lifetime CEI. In adjusted regression models, an increase in 15-year CEI was significantly associated with increased bone Al (β=0.91, 95% confidence interval (CI): 0.16, 1.66). Associations of bone Al with 10- and 20-year CEI were approaching statistical significance (β=0.98, 95% CI: −0.14, 2.1; β=0.59, 95% CI: −0.01, 1.18, respectively). Other models were not statistically significant.
  
  Conclusions
  
  Bone Al was significantly associated with 15-year Al CEI, but not other Al CEIs or fingernail Al. Bone Al may be a useful measure of cumulative, rather than short-term, Al exposure. Additional refinement of this method is ongoing.
  
  
• Keywords:
  Aluminum Biomarker Biomarkers Bone Bone And Bones China Cross-Sectional Studies Cumulative Exposure Index Humans Linear Models Male Mass Spectrometry Middle Aged Nail Neutron Activation Analysis Occupational Exposure

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• Source:
  J Trace Elem Med Biol. 59:126469
• Pubmed ID:
  31982817
• Pubmed Central ID:
  PMC7112220
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; T32 CA147832/CA/NCI NIH HHSUnited States/ ; R21 OH010700/OH/NIOSH CDC HHSUnited States/ ; R13 ES030964/ES/NIEHS NIH HHSUnited States/ ; R01 ES027078/ES/NIEHS NIH HHSUnited States/ ; T03 OH008615/OH/NIOSH CDC HHSUnited States/ ; T03OH008615/ACL/ACL HHSUnited States/
• Volume:
  59
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4d5edf5536027b2d75802733e1130ff1886052bc8e9788fc13432d694ecba2e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/86393/cdc_86393_DS1.pdf
• File Type:
  [PDF - 597.42 KB ]