Characterization of Bone Aluminum, a Potential Biomarker of Cumulative Exposure, Within an Occupational Population from Zunyi, China

Details

• Personal Author:
  Fan Q ; Hasan Z ; Li Y ; Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells EM ; Zheng W ; Zhou J ; Zhou Y
• Description:
  Objectives: Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs). Methods We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and education compared fingernail Al and Al CEIs with bone Al. Results: Median (interquartile range (IQR)) Al measurements were: 15 ug/g dry bone (IQR = 28) for bone Al; 34.9 ug/g (43.3) for fingernail; and 24 (20) for lifetime CEI. In adjusted regression models, an increase in 15-year CEI was significantly associated with increased bone Al (beta = 0.91, 95% confidence interval (CI): 0.16, 1.66). Associations of bone Al with 10- and 20-year CEI were approaching statistical significance (beta = 0.98, 95% CI: -0.14, 2.1; beta = 0.59, 95% CI: -0.01, 1.18, respectively). Other models were not statistically significant. Conclusions: Bone Al was significantly associated with 15-year Al CEI, but not other Al CEIs or fingernail Al. Bone Al may be a useful measure of cumulative, rather than short-term, Al exposure. Additional refinement of this method is ongoing. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Biomarkers Nervous System Occupational Exposure Occupational Health Safety
• Keywords:
  Aluminum Author Keywords: Biomarker Biological Monitoring Bone Chronic Exposure Cross Sectional Studies Cumulative Exposure Index Nail Neurotoxic Agents Neurotoxins Neutron Activation Analysis Occupational Exposure

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• ISSN:
  0946-672X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; Connecticut ; Florida ; Georgia ; Indiana ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• NIOSHTIC Number:
  nn:20059116
• Citation:
  J Trace Elem Med Biol 2020 May; 59:126469
• Contact Point Address:
  Ellen M. Wells, Purdue University, School of Health Sciences, Hampton Hall 1269, 550 Stadium Mall Drive, West Lafayette, IN 7907-2051, USA
• Email:
  wells54@purdue.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Federal Fiscal Year:
  2020
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Journal of Trace Elements in Medicine and Biology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad5f492142aedc6b72f38617dbfdee2bbf9d0341561f2413f7d7e7008da83278f1b876a219cbfaeab80e3e22ec0592b339ee99c2d65e4b34e49ded369d28687a
• Download URL:
  https://stacks.cdc.gov/view/cdc/223430/cdc_223430_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]