DNA methylation signatures as biomarkers of prior environmental exposures

Details

• Alternative Title:
  Curr Epidemiol Rep
• Personal Author:
  Ladd-Acosta, Christine ; Fallin, M. Daniele
• Description:
  Purpose of review:
  
  This review demonstrates the growing body of evidence connecting DNA methylation to prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, and accurate biomarker of past exposure, opening new opportunities for environmental and gene-environment interaction studies among existing banked samples.
  
  Recent findings:
  
  We present the evidence for association between past exposure, including prenatal exposures, and DNA methylation measured at a later time in the life course. We demonstrate the potential utility of DNA methylation-based biomarkers of past exposure using results from multiple studies of smoking as an example. Multiple studies show the ability to accurately predict prenatal smoking exposure based on DNA methylation measured at birth, in childhood, and even adulthood. Separate sets of DNA methylation loci have been used to predict past personal smoking exposure (postnatal) as well. Further, it appears that these two types of exposures, prenatal and previous personal exposure, can be isolated from each other. There is also a suggestion that quantitative methylation scores may be useful for estimating dose. We highlight the remaining needs for rigor in methylation biomarker development including analytic challenges as well as the need for development across multiple developmental windows, multiple tissue types, and multiple ancestries.
  
  Summary:
  
  If fully developed, DNA methylation-based biomarkers can dramatically shift our ability to carry out environmental and genetic-environmental epidemiology using existing biobanks, opening up unprecedented opportunities for environmental health.
  
  
• Subjects:
  Article Biomarker DNA Methylation Environmental Exposure Epigenomic EWAS Past Exposure Prenatal Smoking
• Source:
  Curr Epidemiol Rep. 6(1):1-13
• Pubmed ID:
  31032172
• Pubmed Central ID:
  PMC6481677
• Document Type:
  Journal Article
• Funding:
  AS7659/AS/Autism Speaks/United States ; R01 ES017646/ES/NIEHS NIH HHS/United States ; R01 ES025531/ES/NIEHS NIH HHS/United States ; U01 DD001214/DD/NCBDD CDC HHS/United States
• Volume:
  6
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:32f673a4d810333f691a1cf4f976a3d94b2a8ff75511a11b3943d201adc7bbca
• Download URL:
  https://stacks.cdc.gov/view/cdc/86380/cdc_86380_DS1.pdf
• File Type:
  [PDF - 277.13 KB ]