Details:

Alternative Title:
Osteoporos Int
Personal Author:
Vasikaran, S. D. ; Bhattoa, H. P. ; Eastell, R. ; Heijboer, A. C. ; Jørgensen, N. R. ; ... More +
Vasikaran, S. D. ; Bhattoa, H. P. ; Eastell, R. ; Heijboer, A. C. ; Jørgensen, N. R. ; Makris, K. ; Ulmer, C. ; Kanis, J. A. ; Cooper, C. ; Silverman, S. ; Cavalier, E. Less -
Description:
Introduction

In order to examine the agreement between current commercial assays, a multi-center study was performed for PINP in serum and plasma.

Methods

The automated methods for PINP (Roche Cobas and IDS iSYS) gave similar results. A significant proportional bias was observed between the two automated assays and the Orion radioimmunoassay (RIA) for PINP.

Results

Results from other published studies comparing PINP values among these three assays broadly support our findings. Taken together, these results confirm that harmonized PINP measurements exist between the two automated assays (Roche Cobas and IDS iSYS) when the eGFR is > 30 mL/min/1.73m2, but a significant bias exists between the Orion RIA and the two automated assays.

Conclusion

Therefore, in subjects with normal renal function, PINP results reported by the Roche Cobas and IDS iSYS assays are similar and may be used interchangeably, and similar reference intervals and treatment targets could be applied for the two automated assays. Harmonization between the automated assays and the RIA is potentially possible with the use of common calibrators and the development of a reference method for PINP. This should also help ensure that any new commercial assay developed in the future will attain similar results. IOF and IFCC are committed to working together towards this goal with the cooperation of the reagent manufacturing industry.


Subjects:
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Biological Assay Biomarkers Collagen Type I Humans Peptide Fragments Peptides Procollagen
Source:
Osteoporos Int. 31(3):409-412
Pubmed ID:
31975180
Pubmed Central ID:
PMC7080559
Document Type:
Journal Article
Funding:
MC_U147585827/MRC_/Medical Research Council/United Kingdom ; MC_U147585819/MRC_/Medical Research Council/United Kingdom ; MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom ; CC999999/ImCDC/Intramural CDC HHS/United States ; MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom ; ... More +
MC_U147585827/MRC_/Medical Research Council/United Kingdom ; MC_U147585819/MRC_/Medical Research Council/United Kingdom ; MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom ; CC999999/ImCDC/Intramural CDC HHS/United States ; MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom ; MR/P020941/1/MRC_/Medical Research Council/United Kingdom ; G0400491/MRC_/Medical Research Council/United Kingdom ; MC_U147585824/MRC_/Medical Research Council/United Kingdom Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:adb8d44ffd6b64f83243b54c78df7cce758b365b40374230ff0480eb29578b88
Download URL:
https://stacks.cdc.gov/view/cdc/86016/cdc_86016_DS1.pdf
File Type:

Supporting Files

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