Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

Details

• Alternative Title:
  Clin Chim Acta
• Personal Author:
  Bhattoa, Harjit P. ; Cavalier, Etienne ; Eastell, Richard ; Heijboer, Annemieke C. ; Jørgensen, Niklas R. ; Makris, Konstantinos ; Ulmer, Candice Z. ; Kanis, John A. ; Cooper, Cyrus ; Silverman, Stuart L. ; Vasikaran, Samuel D.
• Description:
  Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
• Subjects:
  Biomarkers Bone Remodeling Collagen Type I Humans Peptide Fragments Peptides Procollagen
• Keywords:
  Bone Formation Bone Resorption Bone Turnover Markers C-terminal Telopeptide Of Type I Collagen Harmonization PINP Procollagen Type I N-propeptide Standardization β-CTX
• Source:
  Clin Chim Acta. 515:16-20
• Pubmed ID:
  33382995
• Pubmed Central ID:
  PMC8033406
• Document Type:
  Journal Article
• Funding:
  MC_UP_A620_1015/MRC_/Medical Research CouncilUnited Kingdom/ ; MR/P020941/1/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UU_12011/1/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UP_A620_1014/MRC_/Medical Research CouncilUnited Kingdom/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; MC_U147585824/MRC_/Medical Research CouncilUnited Kingdom/ ; G0400491/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_U147585819/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UU_12011/2/MRC_/Medical Research CouncilUnited Kingdom/ ; 10/33/04/DH_/Department of HealthUnited Kingdom/ ; MC_ST_U13058/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_PC_21000/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_U147585827/MRC_/Medical Research CouncilUnited Kingdom/
• Volume:
  515
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:62337633da4122f13d5aad055aef8840a3f137663a1ba8fc39e0f5f68c2f1e54
• Download URL:
  https://stacks.cdc.gov/view/cdc/105010/cdc_105010_DS1.pdf
• File Type:
  [PDF - 519.86 KB ]