Details:

Alternative Title:
Clin Chim Acta
Publisher's site:
http://dx.doi.org/10.1016/j.cca.2020.12.023
Personal Author:
Bhattoa, Harjit P. ; Cavalier, Etienne ; Eastell, Richard ; Heijboer, Annemieke C. ; Jørgensen, Niklas R. ; ... More +
Bhattoa, Harjit P. ; Cavalier, Etienne ; Eastell, Richard ; Heijboer, Annemieke C. ; Jørgensen, Niklas R. ; Makris, Konstantinos ; Ulmer, Candice Z. ; Kanis, John A. ; Cooper, Cyrus ; Silverman, Stuart L. ; Vasikaran, Samuel D. ; Less -
Description:
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
Subject:
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Article
Biomarkers
Bone Formation
Bone Remodeling
Bone Resorption
Bone Turnover Markers
C-terminal Telopeptide Of Type I Collagen
Collagen Type I
Harmonization
Humans
Peptide Fragments
Peptides
PINP
Procollagen
Procollagen Type I N-propeptide
Standardization
β-CTX

Source:
Clin Chim Acta. 515:16-20 ;
Pubmed ID:
33382995
Pubmed Central ID:
PMC8033406
Document Type:
Journal Article ;
Funding:
MC_UP_A620_1015/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UU_12011/1/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UP_A620_1014/MRC_/Medical Research CouncilUnited Kingdom/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; MC_U147585827/MRC_/Medical Research CouncilUnited Kingdom/ ; ... More +
MC_UP_A620_1015/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UU_12011/1/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UP_A620_1014/MRC_/Medical Research CouncilUnited Kingdom/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; MC_U147585827/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_U147585824/MRC_/Medical Research CouncilUnited Kingdom/ ; G0400491/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_U147585819/MRC_/Medical Research CouncilUnited Kingdom/ ; MC_UU_12011/2/MRC_/Medical Research CouncilUnited Kingdom/ ; 10/33/04/DH_/Department of HealthUnited Kingdom/ ; MC_ST_U13058/MRC_/Medical Research CouncilUnited Kingdom/ ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:62337633da4122f13d5aad055aef8840a3f137663a1ba8fc39e0f5f68c2f1e54
File Type:

Supporting Files

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  	nihms-1688419-f0001.jpg	jpeg
  	nihms-1688419.nxml	xml

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