Rapid Suppression of Bone Formation Marker in Response to Sleep Restriction and Circadian Disruption in Men

Details

• Alternative Title:
  Osteoporos Int
• Personal Author:
  Swanson, Christine M. ; Kohrt, Wendy M. ; Wolfe, Pamela ; Wright, Kenneth P. ; Shea, Steven A. ; Cain, Sean W. ; Munch, Mirjam ; Vujović, Nina ; Czeisler, Charles A. ; Orwoll, Eric S. ; Buxton, Orfeu M.
• Description:
  PURPOSE:
  
  A serum bone formation marker (procollagen type 1 N-terminal, P1NP) was lower after ~3 weeks of sleep restriction combined with circadian disruption. We now describe the time course of decline.
  
  METHODS:
  
  The ~3 week protocol included two segments: “Baseline,” ≥10 hours (h) sleep opportunity/day x 5 days; “Forced Desynchrony” (FD), recurring 28-h days (circadian disruption) with sleep restriction (~5.6 h sleep per 24 h). Fasted plasma P1NP was measured throughout the protocol in nine men (20–59 years old). We tested the hypothesis that PINP would steadily decline across the FD intervention because the magnitude of sleep loss and circadian misalignment accrued as the protocol progressed. A piecewise linear regression model was used to estimate the slope (β) as ΔP1NP per 24 h with a change point mid-protocol to estimate the initial vs. prolonged effects of FD exposure.
  
  RESULTS:
  
  Plasma P1NP levels declined significantly within the first 10 days of FD (β^= −1.33 μg/L per 24-h, p < 0.0001) and remained lower than baseline with prolonged exposure out to 3 weeks (β^= −0.18 μg/L per 24-h, p = 0.67). As previously reported, levels of a bone resorption marker (C-telopeptide (CTX)) were unchanged.
  
  CONCLUSION:
  
  Sleep restriction with concurrent circadian disruption induced a relatively rapid decline in P1NP (despite no change in CTX) and levels remained lower with ongoing exposure. These data suggest 1) even brief sleep restriction and circadian disruption can adversely affect bone metabolism, and 2) there is no P1NP recovery with ongoing exposure that, taken together, could lead to lower bone density over time.
  
  
• Subjects:
  Adult Biomarkers Circadian Clocks Collagen Type I Humans Male Middle Aged Osteogenesis Peptide Fragments Peptides Procollagen Sleep Sleep Deprivation Sleep Disorders, Circadian Rhythm Young Adult

  More +
• Keywords:
  Bone Formation Bone Loss Circadian Disruption P1NP Sleep Restriction
• Source:
  Osteoporos Int. 30(12):2485-2493
• Pubmed ID:
  31446439
• Pubmed Central ID:
  PMC6879850
• Document Type:
  Journal Article
• Funding:
  K24 HL076446/HL/NHLBI NIH HHSUnited States/ ; R01 HL070848/HL/NHLBI NIH HHSUnited States/ ; UL1 TR000128/TR/NCATS NIH HHSUnited States/ ; U01 AG042145/AG/NIA NIH HHSUnited States/ ; UL1 RR025758-01/RR/NCRR NIH HHSUnited States/ ; U01AG042145/AG/NIA NIH HHSUnited States/ ; UL1 RR025758/RR/NCRR NIH HHSUnited States/ ; U01 AG042139/AG/NIA NIH HHSUnited States/ ; R01 HL125893/HL/NHLBI NIH HHSUnited States/ ; R01 DK099512/DK/NIDDK NIH HHSUnited States/ ; F32 AG051325/AG/NIA NIH HHSUnited States/ ; R01 HL118601/HL/NHLBI NIH HHSUnited States/ ; R01DK099512/DK/NIDDK NIH HHSUnited States/ ; U01AG042143/AG/NIA NIH HHSUnited States/ ; R01HL125893/HL/NHLBI NIH HHSUnited States/ ; U01AG042140/AG/NIA NIH HHSUnited States/ ; R01 HL071194/HL/NHLBI NIH HHSUnited States/ ; R01 HL070847/HL/NHLBI NIH HHSUnited States/ ; U01AG042124/AG/NIA NIH HHSUnited States/ ; U01AR066160/AR/NIAMS NIH HHSUnited States/ ; UL1 TR002369/TR/NCATS NIH HHSUnited States/ ; R01 HL142064/HL/NHLBI NIH HHSUnited States/ ; UL1 TR002535/TR/NCATS NIH HHSUnited States/ ; R01 AG030089/AG/NIA NIH HHSUnited States/ ; R01DK105072/DK/NIDDK NIH HHSUnited States/ ; R01 HL070842/HL/NHLBI NIH HHSUnited States/ ; R01 AG066671/AG/NIA NIH HHSUnited States/ ; U01 AG042124/AG/NIA NIH HHSUnited States/ ; R43 AG056250/AG/NIA NIH HHSUnited States/ ; R01 HL140577/HL/NHLBI NIH HHSUnited States/ ; K23 AR070275/AR/NIAMS NIH HHSUnited States/ ; HFP01601/National Space Biomedical Research Institute (US)/ ; M01 RR002635/RR/NCRR NIH HHSUnited States/ ; U01AG042139/AG/NIA NIH HHSUnited States/ ; K24 HL76446/HL/NHLBI NIH HHSUnited States/ ; U19 OH010154/OH/NIOSH CDC HHSUnited States/ ; F32AG051325/AG/NIA NIH HHSUnited States/ ; U01 AG042168/AG/NIA NIH HHSUnited States/ ; UL1TR000128/TR/NCATS NIH HHSUnited States/ ; R01 HL070841/HL/NHLBI NIH HHSUnited States/ ; U01AG027810/AG/NIA NIH HHSUnited States/ ; P50 HD073063/HD/NICHD NIH HHSUnited States/ ; U01 AG042140/AG/NIA NIH HHSUnited States/ ; R01 HL070838/HL/NHLBI NIH HHSUnited States/ ; P01 AG009975/AG/NIA NIH HHSUnited States/ ; M01 RR02635/RR/NCRR NIH HHSUnited States/ ; PT150133/U.S. Department of Defense (US)/ ; R01 HL070839/HL/NHLBI NIH HHSUnited States/ ; R01HL107240/HL/NHLBI NIH HHSUnited States/ ; R01HL140577/National Heart, Lung, and Blood Institute (US)/ ; U01 AG027810/AG/NIA NIH HHSUnited States/ ; U01AG042168/AG/NIA NIH HHSUnited States/ ; R01HL118601/HL/NHLBI NIH HHSUnited States/ ; R01 HL107240/HL/NHLBI NIH HHSUnited States/ ; R01 HL070837/HL/NHLBI NIH HHSUnited States/ ; R56 AG061085/AG/NIA NIH HHSUnited States/ ; U01 AG042143/AG/NIA NIH HHSUnited States/ ; U01 AR066160/AR/NIAMS NIH HHSUnited States/ ; R01 DK105072/DK/NIDDK NIH HHSUnited States/
• Volume:
  30
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9a2cc400c18071e19b845b7c1efbf46e433d49b401569f74e89b33dcaaefb786
• Download URL:
  https://stacks.cdc.gov/view/cdc/83427/cdc_83427_DS1.pdf
• File Type:
  [PDF - 531.35 KB ]