Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Town, Katy; Harris, Simon; Sánchez-Busó, Leonor; Cole, Michelle J.; Pitt, Rachel; Fifer, Helen; Mohammed, Hamish; Field, Nigel; Hughes, Gwenda

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Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Supporting Files Public Domain

Mar 2020
By Town, Katy ; Harris, Simon ; Sánchez-Busó, Leonor ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Town, Katy ; Harris, Simon ; Sánchez-Busó, Leonor ; Cole, Michelle J. ; Pitt, Rachel ; Fifer, Helen ; Mohammed, Hamish ; Field, Nigel ; Hughes, Gwenda
Description:

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global concern. Phylogenetic analyses resolve uncertainties regarding genetic relatedness of isolates with identical phenotypes and inform whether AMR is due to new mutations and clonal expansion or separate introductions by importation. We sequenced 1,277 isolates with associated epidemiologic and antimicrobial susceptibility data collected during 2013-2016 to investigate N. gonorrhoeae genomic variability in England. Comparing genetic markers and phenotypes for AMR, we identified 2 N. gonorrhoeae lineages with different antimicrobial susceptibility profiles and 3 clusters with elevated MICs for ceftriaxone, varying mutations in the penA allele, and different epidemiologic characteristics. Our results indicate N. gonorrhoeae with reduced antimicrobial susceptibility emerged independently and multiple times in different sexual networks in England, through new mutation or recombination events and by importation. Monitoring and control for AMR in N. gonorrhoeae should cover the entire population affected, rather than focusing on specific risk groups or locations.
Subjects:

AMR Antimicrobial Resistance Antimicrobial Susceptibility Bacteria Ceftriaxone Genomic And Phenotypic Variability Neisseria Gonorrhoeae Antimicrobial Susceptibility, England Gonorrhea Molecular Epidemiology Neisseria Gonorrhoeae PenA Research Whole-genome Sequencing
Source:

Emerg Infect Dis. 26(3):505-515
Pubmed ID:

32091356
Pubmed Central ID:

PMC7045833
Document Type:

Journal Article
Place as Subject:

England
Location:

Europe
Volume:

26
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7799be2b8de1e3278498d786bc92afb6137f9e8dc8c07bc2638c548b2065b4e5
Download URL:

https://stacks.cdc.gov/view/cdc/85673/cdc_85673_DS1.pdf
File Type:

[PDF - 1.95 MB ]

File Language:

English

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