Details:

Alternative Title:
Pathog Dis
Personal Author:
Abrams, A. Jeanine; Trees, David L.;
Abrams, A. Jeanine; Trees, David L.; Less -
Description:
The development of resistance of Neisseria gonorrhoeae to available first-line antibiotics, including penicillins, tetracyclines, fluoroquinolones and cephalosporins, has led to the circulation of multidrug-resistant gonorrhea at a global scale. Advancements in high-throughput whole-genome sequencing (WGS) provide useful tools that can be used to enhance gonococcal detection, treatment and management capabilities, which will ultimately aid in the control of antimicrobial resistant gonorrhea worldwide. In this minireview, we discuss the application of WGS of N. gonorrhoeae to strain typing, phylogenomic, molecular surveillance and transmission studies. We also examine the application of WGS analyses to the public health sector as well as the potential usage of WGS-based transcriptomic and epigenetic methods to identify novel gonococcal resistance mechanisms.
Subject:
[+]
Antimicrobial Resistance
Article
Drug Resistance, Multiple, Bacterial
Gonorrhea
Humans
Molecular Epidemiology
Molecular Typing
Neisseria Gonorrhoeae
Whole-genome Sequencing
Whole Genome Sequencing
Gonorrhea

Source:
Pathog Dis. 75(4);
Pubmed ID:
28387837
Pubmed Central ID:
PMC6956991
Document Type:
Journal Article;
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b3bef71a5d7e27efe2daf50fb054cc78e34549d60e7f67cb7de630a977ae74bb
File Type:

Supporting Files

• nihms-1062768.nxml

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