Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Langley, Joanne M. ; Gantt, Soren ; Quach, Caroline ; Bettinger, Julie A. ; Halperin, Scott A. ; ... More +
Langley, Joanne M. ; Gantt, Soren ; Quach, Caroline ; Bettinger, Julie A. ; Halperin, Scott A. ; Mutch, Jill ; McNeil, Shelly A. ; Ward, Brian J. ; MacKinnon-Cameron, Donna ; Ye, Lingyun ; Marty, Kim ; Scheifele, David ; Brown, Erin ; Alcantara, Joenel Less -
Corporate Authors:
The Canadian Immunization Research Network
Description:
Emergency vaccination programs often are needed to control outbreaks of meningococcal disease caused by Neisseria meningitidis serogroup B (MenB) on college campuses. Such campaigns expend multiple campus and public health resources. We conducted a randomized, controlled, multicenter, observer-blinded trial comparing immunogenicity and tolerability of an accelerated vaccine schedule of 0 and 21 days to a longer interval of 0 and 60 days for 4-component MenB vaccine (MenB-4C) in students 17-25 years of age. At day 21 after the first MenB-4C dose, we observed protective human serum bactericidal titers >4 to MenB strains 5/99, H44/76, and NZ 98/254 in 98%-100% of participants. Geometric mean titers increased >22-fold over baseline. At day 180, >95% of participants sustained protective titers regardless of their vaccine schedule. The most common adverse event was injection site pain. An accelerated MenB-4C immunization schedule could be considered for rapid control of campus outbreaks.
Subjects:
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Adolescent Health Services Adult Disease Outbreaks Double-Blind Method Female Humans Immunization Schedule Male Meningococcal Infections Meningococcal Vaccines Neisseria Meningitidis, Serogroup B Students Universities Vaccination Young Adult
Source:
Emerg Infect Dis. 26(3):454-462
Pubmed ID:
32091358
Pubmed Central ID:
PMC7045834
Document Type:
Journal Article
Place as Subject:
Canada
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:51ae4b3d2d9a7a506b91a126fd786e0f28b4863b862385111417f60eedf230fc
Download URL:
https://stacks.cdc.gov/view/cdc/85661/cdc_85661_DS1.pdf
File Type:

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