Estimating the impact of multiple immunization products on medically-attended respiratory syncytial virus (RSV) infections in infants
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

For very narrow results

When looking for a specific result

Best used for discovery & interchangable words

Recommended to be used in conjunction with other fields

Dates

to

Document Data
Library
People
Clear All
Clear All

For additional assistance using the Custom Query please check out our Help Page

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i

Estimating the impact of multiple immunization products on medically-attended respiratory syncytial virus (RSV) infections in infants

Filetype[PDF-403.50 KB]


English

Details:

  • Alternative Title:
    Vaccine
  • Personal Author:
  • Description:
    Background:

    Palivizumab, a monoclonal antibody and the only licensed immunization product for preventing respiratory syncytial virus (RSV) infection, is recommended for children with certain high-risk conditions. Other antibody products and maternal vaccines targeting young infants are in clinical development. Few studies have compared products closest to potential licensure and have primarily focused on the effects on hospitalizations only. Estimates of the impact of these products on medically-attended (MA) infections in a variety of healthcare settings are needed to assist with developing RSV immunization recommendations.

    Methods:

    We developed a tool for practicing public health officials to estimate the impact of immunization strategies on RSV-associated MA lower respiratory tract infections (LRTIs) in various healthcare settings among infants <12 months. Users input RSV burden and seasonality and examine the influence of altering product efficacy and uptake assumptions. We used the tool to evaluate candidate products’ impacts among a US birth cohort.

    Results:

    We estimated without immunization, 407,360 (range: 339,650–475,980) LRTIs are attended annually in outpatient clinics, 147,240 (126,070–168,510) in emergency departments (EDs), and 33,180 (24,760–42,900) in hospitals. A passive antibody candidate targeting all infants prevented the most LRTIs: 196,470 (48% of visits without immunization) outpatient clinic visits (range: 163,810–229,650), 75,250 (51%) EDs visits (64,430–86,090), and 18,140 (55%) hospitalizations (13,770–23,160). A strategy combining maternal vaccine candidate and palivizumab prevented 58,210 (14% of visits without immunization) LRTIs in outpatient clinics (range: 48,520–67,970), 19,580 (13%) in EDs (16,760–22,400), and 8,190 (25%) hospitalizations (6,390–10,150).

    Conclusions:

    Results underscore the potential for anticipated products to reduce serious RSV illness. Our tool (provided to readers) can be used by different jurisdictions and accept updated data. Results can aid economic evaluations and public health decision-making regarding RSV immunization products.

  • Subjects:
  • Keywords:
  • Source:
  • Pubmed ID:
    31740097
  • Pubmed Central ID:
    PMC7029767
  • Document Type:
  • Funding:
  • Volume:
    38
  • Issue:
    2
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:

You May Also Like

Checkout today's featured content at stacks.cdc.gov