Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening

Details

• Alternative Title:
  Am J Perinatol
• Personal Author:
  Buxton, Miatta A. ; Meraz-Cruz, Noemi ; Sánchez, Brisa N. ; Foxman, Betsy ; Gronlund, Carina J. ; Beltran-Montoya, Jorge ; Castillo-Castrejon, Marisol ; O’Neill, Marie S. ; Vadillo-Ortega, Felipe
• Description:
  Objective
  
  To describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term.
  
  Study Design
  
  We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009–2014). Cytokines were quantified using multiplex assay.
  
  Results
  
  Cytokine distributions differed more between than within cytokines. Across trimesters, cytokines interleukin (IL)-1Ra, IL-1α, and IL-8 consistently had high concentrations compared with other measured cytokines. Cytokine intraclass correlation coefficients ranged from 0.41 to 0.82. Spearman’s correlation coefficients among cytokine pairs varied but correlation directions were stable; 95.3% of the 190 correlation pairs remained either negative or positive across trimesters. Mean longitudinal patterns of log-transformed cytokines from Tobit regression varied across but less within cytokines.
  
  Conclusion
  
  Although mean concentrations of cervicovaginal cytokines among term pregnancies were high, they were largely stable over time. The high cytokine concentrations corroborate that pregnancy is associated with an active inflammatory state. These characterizations may serve as a baseline for comparison to other obstetric outcomes, which may be helpful in understanding deviations from normal gestational inflammation.
  
  
• Subjects:
  Adult Appropriate Statistical Methods Article Body Mass Index Cervix Uteri Cytokines Female Humans Inflammation Longitudinal Data Patterns Pregnancy Pregnancy Trimesters PRINCESA Cohort Reference Values Term Birth Tobit Regression Vagina Young Adult

  More +
• Source:
  Am J Perinatol. 37(6):613-620
• Pubmed ID:
  30978743
• Pubmed Central ID:
  PMC7003200
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHS/United States ; R01 ES016932/ES/NIEHS NIH HHS/United States ; R25 GM058641/GM/NIGMS NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States ; T32 ES007062/ES/NIEHS NIH HHS/United States ; R01 ES017022/ES/NIEHS NIH HHS/United States ; Horace H. Rackham School of Graduate Studies, University of Michigan; National Institute for Environmental Health Sciences/P30 ES017885/International ; Horace H. Rackham School of Graduate Studies, University of Michigan; National Institute for Environmental Health Sciences/R01 ES016932/International ; Horace H. Rackham School of Graduate Studies, University of Michigan; National Institute for Environmental Health Sciences/R01 ES017022/International ; Horace H. Rackham School of Graduate Studies, University of Michigan; National Institute for Environmental Health Sciences/T32 ES007062/International ; National Institute for Occupational Safety and Health/T42 OH008455-09/International ; National Institute of General Medical Sciences/R25GM058641-18/International
• Volume:
  37
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7040ff2200aae8a0fa7d898965c4ce9757f7b64e16ab99cc2961ac882c4ec7cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/84945/cdc_84945_DS1.pdf
• File Type:
  [PDF - 773.07 KB ]