Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy

Details

• Alternative Title:
  Am J Reprod Immunol
• Personal Author:
  Ferguson, Kelly K. ; Kamai, Elizabeth M. ; Cantonwine, David E. ; Mukherjee, Bhramar ; Meeker, John D. ; McElrath, Thomas F.
• Description:
  Problem
  
  Perturbations in normal fetal growth during pregnancy are associated with poor child and adult health outcomes. Inflammation and oxidative stress are recognized as important mechanisms in preeclampsia and preterm birth but have been examined less in relation to fetal growth. We hypothesized that maternal inflammation and oxidative stress in pregnancy would be associated with reduced fetal growth and sought to identify windows of vulnerability.
  
  Method of study
  
  In a secondary analysis of 482 women from the LIFECODES birth cohort study, we measured inflammation (C-Reactive Protein [CRP] and the cytokines IL-1β, IL-6, IL-10, and TNF-α) and oxidative stress (8-isoprostane and 8-hydroxydeoxyguanosine [8-OHdG]) biomarkers in plasma and urine, respectively, at four time points during pregnancy. We examined associations between repeated measures of each marker and ultrasound (head and abdominal circumference, femur length, and a summary measure of estimated fetal weight) as well as delivery (birth weight) metrics of growth.
  
  Results
  
  In adjusted repeated measures models, an interquartile range (IQR) increase in CRP was associated with a 0.12 standard deviation decrease in fetal weight z-score (95% confidence interval, CI, −0.21, −0.02), which corresponds to approximately 50 grams at 40 weeks gestation. The association was greatest in magnitude (i.e., most negative) with CRP measured later in pregnancy. Oxidative stress markers were not associated with fetal weight, although both were inversely associated with head circumference and femur length.
  
  Conclusions
  
  Inflammation and oxidative stress markers measured later in pregnancy were associated with reduced fetal growth as measured by repeated ultrasound scans.
  
  
• Subjects:
  8-Hydroxy-2'-Deoxyguanosine Adult Biomarkers Birth Weight Cytokines Deoxyguanosine Dinoprost Female Fetal Development Humans Infant, Newborn Inflammation Male Oxidative Stress Pregnancy Ultrasonography, Prenatal Young Adult

  More +
• Keywords:
  Biomarkers Birth Weight Circulation Cytokines Inflammation Intrauterine Growth Restriction Isoprostane
• Source:
  Am J Reprod Immunol. 80(4):e13017
• Pubmed ID:
  29984454
• Pubmed Central ID:
  PMC6160349
• Document Type:
  Journal Article
• Funding:
  P42 ES017198/ES/NIEHS NIH HHSUnited States/ ; T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 ES018872/ES/NIEHS NIH HHSUnited States/ ; T32 ES007018/ES/NIEHS NIH HHSUnited States/ ; ZIA ES103321-01/Intramural NIH HHSUnited States/ ; 9MZ-04-06N03/Abbott Diagnostics DivisionInternational/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; ZIA103313/ES/NIEHS NIH HHSUnited States/ ; Z99 ES999999/Intramural NIH HHSUnited States/
• Volume:
  80
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:fb9ff6f47d4e3c9f3415517f853788e33a6da620ad1c1ae4fcc4a71265e3057497106e6c8ca10571729afe077d51e7a94028ce02687e0dce06dc6f5116e23d88
• Download URL:
  https://stacks.cdc.gov/view/cdc/76890/cdc_76890_DS1.pdf
• File Type:
  [PDF - 455.67 KB ]