Repeated Measures of Cervicovaginal Cytokines During Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening

Details

• Personal Author:
  Beltran-Montoya J ; Buxton MA ; Castillo-Castrejon M ; Foxman B ; Gronlund CJ ; Meraz-Cruz N ; O'Neill MS ; Sánchez BN ; Vadillo-Ortega F
• Description:
  Objective: This study aimed to describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term. Study Design: We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009-2014). Cytokines were quantified using multiplex assay. Results: Cytokine distributions differed more between than within cytokines. Across trimesters, cytokines interleukin (IL)-1Ra, IL-1a, and IL-8 consistently had high concentrations compared with other measured cytokines. Cytokine intraclass correlation coefficients ranged from 0.41 to 0.82. Spearman's correlation coefficients among cytokine pairs varied but correlation directions were stable; 95.3% of the 190 correlation pairs remained either negative or positive across trimesters. Mean longitudinal patterns of log-transformed cytokines from Tobit regression varied across but less within cytokines. Conclusion: Although mean concentrations of cervicovaginal cytokines among term pregnancies were high, they were largely stable over time. The high cytokine concentrations corroborate that pregnancy is associated with an active inflammatory state. These characterizations may serve as a baseline for comparison to other obstetric outcomes, which may be helpful in understanding deviations from normal gestational inflammation. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Occupational Health Pregnancy Safety Women
• Keywords:
  Author Keywords: Appropriate Statistical Methods Cohort Studies Cytokines Inflammation Longitudinal Data Longitudinal Study Medical Screening Patterns PRINCESA Cohort Statistical Analysis Term Birth Tobit Regression

  More +
• ISSN:
  0735-1631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  37
• Issue:
  6
• NIOSHTIC Number:
  nn:20059391
• Citation:
  Am J Perinatol 2020 May; 37(6):613-620
• Contact Point Address:
  Miatta A. Buxton, PhD, MPH, Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Room 6665, Ann Arbor, MI 48109-2029
• Email:
  mabuxton@umich.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Perinatology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:834db527d41440cd2ee42d610b384f95260fa68017d25873381a9f6c9379b38e7f1cd88647512334aac28397e95c8a7110feeec04690c3b16c4bda2675763e86
• Download URL:
  https://stacks.cdc.gov/view/cdc/223646/cdc_223646_DS1.pdf
• File Type:
  [PDF - 253.23 KB ]