Assessment of executive function declines in presymptomatic and
mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential
clinical trial endpoint

Staffaroni, Adam M.; Bajorek, Lynn; Casaletto, Kaitlin B.; Cobigo, Yann; Goh, Sheng-Yang M.; Wolf, Amy; Heuer, Hilary W.; Elahi, Fanny M.; Ljubenkov, Peter A.; Dever, Reilly; Kornak, John; Appleby, Brian; Bove, Jessica; Bordelon, Yvette; Brannelly, Patrick; Brushaber, Danielle; Caso, Christina; Coppola, Giovanni; Dheel, Christina; Dickerson, Bradford C.; Dickinson, Susan; Dominguez, Sophia; Domoto-Reilly, Kimiko; Faber, Kelly; Ferrall, Jessica; Fields, Julie A.; Fishman, Ann; Fong, Jamie; Foroud, Tatiana; Forsberg, Leah K.; Gavrilova, Ralitza; Gearhart, Debra; Ghazanfari, Behnaz; Ghoshal, Nupur; Goldman, Jill; Graff-Radford, Jonathan; Graff-Radford, Neill; Grant, Ian; Grossman, Murray; Haley, Dana; Hsiung, Ging-Yuek; Huey, Edward D.; Irwin, David J.; Jones, David T.; Jones, Lynne; Kantarci, Kejal; Karydas, Anna; Kaufer, Daniel I.; Kerwin, Diana R.; Knopman, David S.; Kraft, Ruth; Kremers, Walter K.; Kukull, Walter A.; Litvan, Irene; Lucente, Diane; Lungu, Codrin; Mackenzie, Ian R.; Maldonado, Miranda; Manoochehri, Masood; McGinnis, Scott M.; McKinley, Emily; Mendez, Mario F.; Miller, Bruce L.; Multani, Namita; Onyike, Chiadi; Padmanabhan, Jaya; Pantelyat, Alex; Pearlman, Rodney; Petrucelli, Len; Potter, Madeline; Rademakers, Rosa; Ramos, Eliana Marisa; Rankin, Katherine P.; Rascovsky, Katya; Roberson, Erik D.; Rogalski, Emily; Sengdy, Pheth; Shaw, Leslie M.; Syrjanen, Jeremy; Tartaglia, M. Carmela; Tatton, Nadine; Taylor, Joanne; Toga, Arthur; Trojanowski, John Q.; Weintraub, Sandra; Wang, Ping; Wong, Bonnie; Wszolek, Zbigniew; Boxer, Adam L.; Boeve, Brad F.; Kramer, Joel H.; Rosen, Howard J.

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Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

Published Date:

January 2020

Source:

Alzheimers Dement. 16(1):11-21

Language:

English

[PDF-439.30 KB]

Details:

Alternative Title:

Alzheimers Dement

Personal Author:

Staffaroni, Adam M. ; Bajorek, Lynn ; Casaletto, Kaitlin B. ; Cobigo, Yann ; Goh, Sheng-Yang M. ; ... More ▼

Description:

Introduction: Identifying clinical measures that track disease in the earliest stages of frontotemporal lobar degeneration (FTLD) is important for clinical trials. Familial FTLD provides a unique paradigm to study early FTLD. Executive dysfunction is a clinically relevant hallmark of FTLD and may be a marker of disease progression. Methods: Ninety-three mutation carriers with no symptoms or minimal/questionable symptoms (MAPT, n = 31; GRN,n = 28; C9orf72,n = 34; Clinical Dementia Rating scale plus NACC FTLD Module <1) and 78 noncarriers enrolled through Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects studies completed the Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (NIH-EXAMINER) and the UDS neuropsychological battery. Linear mixed-effects models were used to identify group differences in cognition at baseline and longitudinally. We examined associations between cognition, clinical functioning, and magnetic resonance imaging volumes. Results: NIH-EXAMINER scores detected baseline and differences in slopes between carriers and noncarriers, even in carriers with a baseline Clinical Dementia Rating scale plus NACC FTLD Module = 0. NIH-EXAMINER declines were associated with worsening clinical symptoms and brain volume loss. Discussion: The NIH-EXAMINER is sensitive to cognitive changes in presymptomatic familial FTLD and is a promising surrogate endpoint.

Subject:

[+]

Pubmed ID:

31914230

Pubmed Central ID:

PMC6842665

Document Type:

Journal Article

Funding:

Biogen/International ; K24 AG045333/AG/NIA NIH HHS/United States ; U24 AG021886/AG/NIA NIH HHS/United States ; P01 AG017586/AG/NIA NIH HHS/United States ; Genentech/International ; ... More ▼

Collection(s):

CDC Public Access

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Supporting Files:

	nihms-1055072-f0001.gif	image/gif
	nihms-1055072-f0001.jpg	image/jpeg
	nihms-1055072.nxml	text/xml
	NIHMS1055072-supplement-Supplemental_Methods.pdf	application/pdf
	NIHMS1055072-supplement-Supplemental_Table_1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document

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Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

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