Plasma p-tau181 shows stronger network association to Alzheimer’s disease dementia than neurofilament light and total tau

Details

• Alternative Title:
  Alzheimers Dement
• Personal Author:
  Frank, Brandon ; Ally, Madeline ; Brekke, Bailee ; Zetterberg, Henrik ; Blennow, Kaj ; Sugarman, Michael A. ; Ashton, Nicholas J. ; Karikari, Thomas K. ; Tripodis, Yorghos ; Martin, Brett ; Palmisano, Joseph N. ; Steinberg, Eric G. ; Simkina, Irene ; Turk, Katherine W. ; Budson, Andrew E. ; O’Connor, Maureen K. ; Au, Rhoda ; Goldstein, Lee E. ; Jun, Gyungah R. ; Kowall, Neil W. ; Stein, Thor D. ; McKee, Ann C. ; Killiany, Ronald ; Qiu, Wei Qiao ; Stern, Robert A. ; Mez, Jesse ; Alosco, Michael L.
• Description:
  Introduction:
  
  We examined the ability of plasma hyperphosphorylated tau (p-tau)181 to detect cognitive impairment due to Alzheimer’s disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL).
  
  Methods:
  
  Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables.
  
  Results:
  
  Plasma p-tau181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau181 had a direct association with cognitive diagnosis in a bootstrapped GGM.
  
  Discussion:
  
  These results support plasma p-tau181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
  
  
• Subjects:
  Alzheimer Disease Biomarkers Cognitive Dysfunction Humans Intermediate Filaments Tau Proteins
• Keywords:
  Alzheimer's Disease Alzheimer's Disease Sequencing Project Alzheimer’s Disease Antiviral Agents Herpes Simplex Human Papillomavirus Network Analysis Neuropsychology P-tau Plasma Biomarkers Torque Teno Viruses Whole Exome Sequencing Whole Genome Sequencing

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• Source:
  Alzheimers Dement. 18(8):1523-1536
• Pubmed ID:
  34854549
• Pubmed Central ID:
  PMC9160800
• Document Type:
  Journal Article
• Funding:
  RF1 AG057768/AG/NIA NIH HHSUnited States/ ; IK2 CX002065/CX/CSRD VAUnited States/ ; R01 HD090191/HD/NICHD NIH HHSUnited States/ ; U24 AG061340/AG/NIA NIH HHSUnited States/ ; K23 NS102399/NS/NINDS NIH HHSUnited States/ ; R01 AG068398/AG/NIA NIH HHSUnited States/ ; R01 AG062624/AG/NIA NIH HHSUnited States/ ; I01 CX001038/CX/CSRD VAUnited States/ ; U01 AG062602/AG/NIA NIH HHSUnited States/ ; R01 OH011511/OH/NIOSH CDC HHSUnited States/ ; R01 AG037639/AG/NIA NIH HHSUnited States/ ; R01 AG058822/AG/NIA NIH HHSUnited States/ ; R01 AG069453/AG/NIA NIH HHSUnited States/ ; R56 AG069130/AG/NIA NIH HHSUnited States/ ; R01 AG016495/AG/NIA NIH HHSUnited States/ ; R44 AG063635/AG/NIA NIH HHSUnited States/ ; U01 AG032984/AG/NIA NIH HHSUnited States/ ; R01 AG049810/AG/NIA NIH HHSUnited States/ ; R01 AG061028/AG/NIA NIH HHSUnited States/ ; U01 NS086659/NS/NINDS NIH HHSUnited States/ ; RF1 AG062109/AG/NIA NIH HHSUnited States/ ; U01 AG068057/AG/NIA NIH HHSUnited States/ ; R01 AG062348/AG/NIA NIH HHSUnited States/ ; U01 NS093334/NS/NINDS NIH HHSUnited States/ ; P30 AG013846/AG/NIA NIH HHSUnited States/ ; I01 BX002466/BX/BLRD VAUnited States/ ; P30 AG072978/AG/NIA NIH HHSUnited States/ ; U54 NS115266/NS/NINDS NIH HHSUnited States/ ; R01 AG029672/AG/NIA NIH HHSUnited States/ ; R01 HL141774/HL/NHLBI NIH HHSUnited States/ ; R01 AG059011/AG/NIA NIH HHSUnited States/ ; R01 AG049899/AG/NIA NIH HHSUnited States/ ; R01 AG033040/AG/NIA NIH HHSUnited States/ ; R01 AG048927/AG/NIA NIH HHSUnited States/ ; R56 AG062109/AG/NIA NIH HHSUnited States/ ; R01 AG055337/AG/NIA NIH HHSUnited States/ ; I01 BX004613/BX/BLRD VAUnited States/ ; RF1 AG057902/AG/NIA NIH HHSUnited States/ ; U19 AG068753/AG/NIA NIH HHSUnited States/ ; R01 AG070883/AG/NIA NIH HHSUnited States/ ; UL1 TR001430/TR/NCATS NIH HHSUnited States/ ; RF1 AG054156/AG/NIA NIH HHSUnited States/
• Volume:
  18
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:e0b52f7bce9ce35054017a7934118605d27203cdf17bb3349a051f9ac6f36daf4d156b047c8c5b2783f52eb360826b8fa10957f726835aaeebc47f6a6471d0a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/119213/cdc_119213_DS1.pdf
• File Type:
  [PDF - 969.09 KB ]