Details:

Alternative Title:
Ann Am Thorac Soc
Personal Author:
Wilson, John W. ; Nilsen, Diana M. ; Marks, Suzanne M.
Wilson, John W. ; Nilsen, Diana M. ; Marks, Suzanne M. Less -
Description:
The management of multidrug-resistant tuberculosis (MDR TB) is notably complex among patients with human immunodeficiency virus (HIV). TB treatment recommendations typically include very little information specific to HIV and MDR TB, which often is derived from clinical trials conducted in low-resource settings. Mortality rates among patients with HIV and MDR TB remain high. We reviewed the published literature and recommendations to synthesize possible patient management approaches demonstrated to improve treatment outcomes in high-resourced countries for patients with MDR TB and HIV. Approaches to diagnostic testing, impact and timing of antiretroviral therapy on mortality, anti-MDR TB and antiretroviral drug interactions, and the potential role for short-course MDR TB therapy are examined. The combination of antiretroviral therapy with expanded TB drug therapy, along with the management of immune reconstitution inflammatory syndrome, other potential HIV-associated opportunistic diseases, and drug toxicities, necessitate an integrated multidisciplinary patient care approach using public health case management and provider expertise in drug-resistant TB and HIV management.
Subject:
[+]
Article
HIV
MDR TB
Tuberculosis

Source:
Ann Am Thorac Soc. 17(1):16-23
Pubmed ID:
31365831
Pubmed Central ID:
PMC6938532
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0ae6c9f7b613f6b632dbd99f1f13811f5c7f9f59c78ee564979ae5ecb9ecbcb3
File Type:

Supporting Files

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