Details:

Alternative Title:
Int J Tuberc Lung Dis
Personal Author:
Chen, M. P. ; Miramontes, R. ; Kammerer, J. S.
Chen, M. P. ; Miramontes, R. ; Kammerer, J. S. Less -
Description:
OBJECTIVE :

To determine risk factors for multidrug-resistant tuberculosis (MDR-TB) and describe MDR-TB according to three characteristics: previous TB disease, recent transmission of MDR-TB, and reactivation of latent MDR-TB infection.

SETTING AND DESIGN :

We used 2011–2016 surveillance data from the US National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service and used logistic regression models to estimate risk factors associated with MDR-TB.

RESULTS :

A total of 615/45 209 (1.4%) cases were confirmed as MDR-TB; 111/615 (18%) reported previous TB disease; 41/615 (6.7%) were attributed to recent MDR-TB transmission; and 449/615 (73%) to reactivation. Only 12/41 (29%) patients with TB attributed to recent transmission were known to be contacts of someone with MDR-TB. For non-US-born patients, the adjusted odds ratios of having MDR-TB were 32.6 (95%CI 14.6–72.6) among those who were known to be contacts of someone with MDR-TB and 6.5 (95%CI 5.1–8.3) among those who had had previous TB disease.

CONCLUSION :

The majority of MDR-TB cases in the United States were associated with previous TB disease or reactivation of latent MDR-TB infection; only a small proportion of MDR-TB cases were associated with recent transmission.


Subject:
[+]
Antitubercular Agents
Humans
Logistic Models
Mycobacterium Tuberculosis
Odds Ratio
Risk Factors
Tuberculosis
Tuberculosis, Multidrug-Resistant

Source:
Int J Tuberc Lung Dis. 24(1):92-99
Pubmed ID:
32005311
Pubmed Central ID:
PMC8116816
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:33df16aa2ca138cef667f3fdd9e399c5beaba1752661c7d9f15dd6b3a1f30e9b
File Type:

Supporting Files

• nihms-1699249.nxml

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