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Multidrug-resistant tuberculosis in the United States, 2011–2016: patient characteristics and risk factors

Supporting Files
File Language:
English


Details

  • Alternative Title:
    Int J Tuberc Lung Dis
  • Personal Author:
  • Description:
    OBJECTIVE :

    To determine risk factors for multidrug-resistant tuberculosis (MDR-TB) and describe MDR-TB according to three characteristics: previous TB disease, recent transmission of MDR-TB, and reactivation of latent MDR-TB infection.

    SETTING AND DESIGN :

    We used 2011–2016 surveillance data from the US National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service and used logistic regression models to estimate risk factors associated with MDR-TB.

    RESULTS :

    A total of 615/45 209 (1.4%) cases were confirmed as MDR-TB; 111/615 (18%) reported previous TB disease; 41/615 (6.7%) were attributed to recent MDR-TB transmission; and 449/615 (73%) to reactivation. Only 12/41 (29%) patients with TB attributed to recent transmission were known to be contacts of someone with MDR-TB. For non-US-born patients, the adjusted odds ratios of having MDR-TB were 32.6 (95%CI 14.6–72.6) among those who were known to be contacts of someone with MDR-TB and 6.5 (95%CI 5.1–8.3) among those who had had previous TB disease.

    CONCLUSION :

    The majority of MDR-TB cases in the United States were associated with previous TB disease or reactivation of latent MDR-TB infection; only a small proportion of MDR-TB cases were associated with recent transmission.

  • Subjects:
  • Keywords:
  • Source:
    Int J Tuberc Lung Dis. 24(1):92-99
  • Pubmed ID:
    32005311
  • Pubmed Central ID:
    PMC8116816
  • Document Type:
    Journal Article
  • Funding:
    CC999999/ImCDC/Intramural CDC HHSUnited States/
  • Place as Subject:
    United States
  • Volume:
    24
  • Issue:
    1
  • Collection(s):
  • Main Document Checksum:
    urn:sha256:33df16aa2ca138cef667f3fdd9e399c5beaba1752661c7d9f15dd6b3a1f30e9b
  • Download URL:
  • File Type:
    Filetype[PDF - 110.86 KB ]

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