Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Chen, Yong ; Dong, Fengshou ; Zhao, Jingya ; Fan, Hong ; Qin, Chunping ; ... More +
Chen, Yong ; Dong, Fengshou ; Zhao, Jingya ; Fan, Hong ; Qin, Chunping ; Li, Runan ; Verweij, Paul E. ; Zheng, Yongquan ; Han, Li Less -
Description:
In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields in China. Using 63 soil cores, we cultured for azole-resistant A. fumigatus and characterized isolates by their cyp51A gene type, short tandem repeat genotype, and mating type. Of 206 A. fumigatus isolates, 21 (10.2%) were azole resistant. Nineteen of 21 had mutations in their cyp51A gene (5 TR34/L98H, 8 TR34/L98H/S297T/F495I, 6 TR46/Y121F/T289A). Eighteen were cultured from soil samples acquired from strawberry fields, suggesting this soil type is a potential hotspot for azole resistance selection. Twenty resistant isolates were mating type MAT1-1, suggesting asexual sporulation contributed to their evolution. Prochloraz, difenoconazole, and tebuconazole were the most frequently detected fungicides in soil samples with azole-resistant fungus. Our study results suggest that managing the fungicides used in agriculture will help contain the problem of antifungal drug resistance in clinics.
Subject:
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Agriculture
Antifungal Drug Resistance
Antimicrobial Resistance
Asexual Reproduction
Asexual Sporulation
Aspergillus Fumigatus
Azole Fungicides
Azole Resistance
Cyp51A
Epidemiology
Farms
Fungi
High Azole Resistance In Aspergillus Fumigatus Isolates From Strawberry Fields, China, 2018
MAT1-1
Research
Resistance Hotspot
Short Tandem Repeat Typing
Strawberries
Strawberry Fields
STR Type

Source:
Emerg Infect Dis. 26(1):81-89
Pubmed ID:
31855142
Pubmed Central ID:
PMC6924917
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9efb11b4d74d289ec73d6a3557e96c352b5a4f53927afe99f923422eaca36120
File Type:

Supporting Files

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