Cardiopulmonary Health Effects of Airborne Particulate Matter: Correlating Animal Toxicology to Human Epidemiology

Details

• Alternative Title:
  Toxicol Pathol
• Personal Author:
  Pinkerton, Kent E. ; Chen, Chao-Yin ; Mack, Savannah M. ; Upadhyay, Priya ; Wu, Ching-Wen ; Yuan, Wanjun
• Description:
  The effects of particulate matter (PM) on cardiopulmonary health have been studied extensively over the past three decades. Particulate matter is the primary criteria air pollutant most commonly associated with adverse health effects on the cardiovascular and respiratory systems. The mechanisms by which PM exerts its effects are thought to be due to a variety of factors which may include, but are not limited to, concentration, duration of exposure, and age of exposed persons. Adverse effects of PM are strongly driven by their physicochemical properties, sites of deposition, and interactions with cells of the respiratory and cardiovascular systems. The direct translocation of particles, as well as neural and local inflammatory events, are primary drivers for the observed cardiopulmonary health effects. In this review, toxicological studies in animals, and clinical and epidemiological studies in humans are examined to demonstrate the importance of using all three approaches to better define potential mechanisms driving health outcomes upon exposure to airborne PM of diverse physicochemical compositions.
• Subjects:
  Air Pollutants Animals Article Cardiopulmonary Cardiovascular Diseases Elderly Fibrosis Heart Rate Heart Rate Variability Humans Inflammation Inhalation Exposure Lung Diseases Neonates Particulate Matter Species Specificity

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• Source:
  Toxicol Pathol. 47(8):954-961
• Pubmed ID:
  31645209
• Pubmed Central ID:
  PMC6911013
• Document Type:
  Journal Article
• Funding:
  P51 OD011107/OD/NIH HHS/United States ; T32 ES007059/ES/NIEHS NIH HHS/United States ; P30 ES023513/ES/NIEHS NIH HHS/United States ; U01 ES027288/ES/NIEHS NIH HHS/United States ; U42 OD011197/OD/NIH HHS/United States ; U54 OH007550/OH/NIOSH CDC HHS/United States ; U01 OH010969/OH/NIOSH CDC HHS/United States ; R01 ES025229/ES/NIEHS NIH HHS/United States
• Volume:
  47
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9ae65d9f2a58f21e6434def99869d15b11274ff874055cb32c1c03d28ec9b6d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/83575/cdc_83575_DS1.pdf
• File Type:
  [PDF - 2.73 MB ]