Cardiopulmonary Health Effects of Airborne Particulate Matter: Correlating Animal Toxicology to Human Epidemiology

Details

• Personal Author:
  Chen C-Y ; Mack SM ; Pinkerton KE ; Upadhyay P ; Wu C-W ; Yuan W
• Description:
  The effects of particulate matter (PM) on cardiopulmonary health have been studied extensively over the past three decades. Particulate matter is the primary criteria air pollutant most commonly associated with adverse health effects on the cardiovascular and respiratory systems. The mechanisms by which PM exerts its effects are thought to be due to a variety of factors which may include, but are not limited to, concentration, duration of exposure, and age of exposed persons. Adverse effects of PM are strongly driven by their physicochemical properties, sites of deposition, and interactions with cells of the respiratory and cardiovascular systems. The direct translocation of particles, as well as neural and local inflammatory events, are primary drivers for the observed cardiopulmonary health effects. In this review, toxicological studies in animals, and clinical and epidemiological studies in humans are examined to demonstrate the importance of using all three approaches to better define potential mechanisms driving health outcomes upon exposure to airborne PM of diverse physicochemical compositions. [Description provided by NIOSH]
• Subjects:
  Dust Epidemiology Occupational Health Particulate Matter Safety Toxicology
• Keywords:
  Author Keywords: Cardiopulmonary Cardiopulmonary System Elderly Individuals Fibrosis Health Effects Heart Rate Variability Inflammation Neonates Particulate Dust Particulates
• ISSN:
  0192-6233
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  47
• Issue:
  8
• NIOSHTIC Number:
  nn:20058180
• Citation:
  Toxicol Pathol 2019 Dec; 47(8):954-961
• Contact Point Address:
  Kent E. Pinkerton, Center for Health and the Environment, University of California, One Shields Avenue, Davis, CA 95616, USA
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California at Davis
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Toxicologic Pathology
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8027f1ea2a09d7cf570fdfdd64e453e233c813b419d0a7b2e9376ada67995fdf4b2ff87f7fa114ae25dfa8decf5dd1f682dc1f28ad5002b89fc01a78e0488a1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/221317/cdc_221317_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]