Ambient Air Pollution Alters Heart Rate Regulation in Aged Mice

Details

• Personal Author:
  Breysse PN ; Dominici F ; Geyh A ; Ramos-Bonilla JP ; Tankersley CG
• Description:
  Context: Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. Objective: Determine the association at different time-lags between the complex mixture of ambient concentrations of PM, carbon monoxide (CO), and nitrogen dioxide (NO2), and markers of cardiac function in a model of aged mice. Materials and methods: AKR/J inbred mice were exposed to ambient air, 6h daily for 40 weekdays. During this period, the animals' electrocardiogram (ECG), deep body temperature (Tdb), and body weight (BW) were registered, and concentrations of PM, CO, NO2, as well as air temperature and relative humidity (RH) were measured. Data analysis included random effects models with lagged covariate methods. Results: CO was significantly associated with declines in heart rate (HR) and heart rate variability (HRV), PM was significantly associated with declines in HRV and BW, and NO2 was significantly associated with declines in HR. Some significant associations occurred in the same day (PM and HRV, PM and BW, CO and HR), whereas others were delayed by 1 to 3 days (CO and HR, CO and HRV, NO2 and HR, PM and HRV). Discussion and conclusion: Finding significant declines in heart function in aged mice associated with the combined effects of air pollutants at ambient concentrations and at different time-lags is of great importance to public health. These results further implicate the potential short term and delayed effects of air pollution on HR alterations. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollutants, Occupational Air Pollution Animals Cardiovascular System Occupational Health Particulate Matter Safety
• Keywords:
  Airborne Particulates Air Pollutants Air Pollution Animal Studies Author Keywords: Particulate Matter Cardiac Function Gaseous Pollutants Heart Rate Heart Rate Variability Longitudinal Data Analysis Longitudinal Study Particulates

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  330-339
• Volume:
  22
• Issue:
  4
• NIOSHTIC Number:
  nn:20062756
• Citation:
  Inhal Toxicol 2010 Mar; 22(4):330-339
• Contact Point Address:
  Clarke G. Tankersley, PhD, Division of Physiology, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Room E7612, Baltimore, MD 21205, USA
• Email:
  ctankers@jhsph.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0) ; Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2010
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1f5c55df3fea722192931534d85bf618c83007cbd74f9ec3d516d577f7dbc6d3e565529bd97c724f65178f024c85460c9a2a9d160aca58e35e58de0b9e018a32
• Download URL:
  https://stacks.cdc.gov/view/cdc/225946/cdc_225946_DS1.pdf
• File Type:
  [PDF - 844.65 KB ]