Details:

Alternative Title:
Vaccine
Personal Author:
Donahue, James G. ; Kieke, Burney A. ; King, Jennifer P. ; Mascola, Maria A. ; Shimabukuro, Tom T. ; ... More +
Donahue, James G. ; Kieke, Burney A. ; King, Jennifer P. ; Mascola, Maria A. ; Shimabukuro, Tom T. ; DeStefano, Frank ; Hanson, Kayla E. ; McClure, David L. ; Olaiya, Oluwatosin ; Glanz, Jason M. ; Hechter, Rulin C. ; Irving, Stephanie A. ; Jackson, Lisa A. ; Klein, Nicola P. ; Naleway, Allison L. ; Weintraub, Eric S. ; Belongia, Edward A. Less -
Description:
Introduction:

A recent study reported an association between inactivated influenza vaccine (IIV) and spontaneous abortion (SAB), but only among women who had also been vaccinated in the previous influenza season. We sought to estimate the association between IIV administered in three recent influenza seasons and SAB among women who were and were not vaccinated in the previous influenza season.

Methods:

We conducted a case-control study over three influenza seasons (2012–13, 2013–14, 2014–15) in the Vaccine Safety Datalink (VSD). Cases (women with SAB) and controls (women with live births) were matched on VSD site, date of last menstrual period, age group, and influenza vaccination status in the previous influenza season. Of 1908 presumptive cases identified from the electronic record, 1236 were included in the main analysis. Administration of IIV was documented in several risk windows, including 1–28, 29–56, and >56 days before the SAB date.

Results:

Among 627 matched pairs vaccinated in the previous season, no association was found between vaccination in the 1–28 day risk window and SAB (adjusted odds ratio (aOR) 0.9; 95% confidence interval (CI) 0.6–1.5). The season-specific aOR ranged from 0.5 to 1.7 with all CIs including the null value of 1.0. Similarly, no association was found among women who were not vaccinated in the previous season; the season-specific aOR in the 1–28 day risk window ranged from 0.6 to 0.7 and the 95% CI included 1.0 in each season. There was no association found between SAB and influenza vaccination in the other risk windows, or when vaccine receipt was analyzed relative to date of conception.

Conclusion:

During these seasons we found no association between IIV and SAB, including among women vaccinated in the previous season. These findings lend support to current recommendations for influenza vaccination at any time during pregnancy, including the first trimester.


Subject:
[+]
Abortion, Spontaneous
Adolescent
Adult
Article
Case-Control Studies
Female
History, 21st Century
Humans
Influenza
Influenza Vaccine
Influenza Vaccines
Odds Ratio
Pregnancy
Public Health Surveillance
Seasons
Spontaneous Abortion
Vaccination
Vaccines, Inactivated
Young Adult

Source:
Vaccine. 37(44):6673-6681
Pubmed ID:
31540812
Pubmed Central ID:
PMC6906603
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:474e3e9ddeeb860944300c890091abda4ee1eb0e020a1240bc1d254c09421ab3
File Type:

Supporting Files

• 	nihms-1061983-f0001.gif	gif
  	nihms-1061983-f0001.jpg	jpeg
  	nihms-1061983.nxml	xml
  	NIHMS1061983-supplement-Suppl.docx	docx

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