Details:

Alternative Title:
Arthritis Care Res (Hoboken)
Publisher's site:
http://dx.doi.org/10.1002/acr.23925
Personal Author:
Charoenwoodhipong, Prae ; Harlow, Sioban D. ; Marder, Wendy ; Hassett, Afton L. ; McCune, W. Joseph ; ... More +
Charoenwoodhipong, Prae ; Harlow, Sioban D. ; Marder, Wendy ; Hassett, Afton L. ; McCune, W. Joseph ; Gordon, Caroline ; Helmick, Charles G. ; Barbour, Kamil E. ; Wang, Lu ; Mancuso, Peter ; Somers, Emily C. ; Zick, Suzanna M. Less -
Description:
Objective:

To examine associations between dietary intake of omega-3 (n-3; generally anti-inflammatory) and omega-6 (n-6; generally pro-inflammatory) fatty acids and patient-reported outcomes in systemic lupus erythematosus (SLE).

Methods:

This study was based on the population-based Michigan Lupus Epidemiology & Surveillance (MILES) Cohort. Estimates of n-3 and n-6 intake were derived from Diet History Questionnaire II items (DHQ II; past year with portion size version). Patient-reported outcomes included self-reported lupus activity (Systemic Lupus Activity Questionnaire/SLAQ). Multivariable regression, adjusted for age, sex, race, and body mass index, was used to assess associations between absolute intake of n-3 and n-6, as well as the n-6:n-3 ratio, and patient-reported outcomes.

Results:

Among 456 SLE cases, 425 (93.2%) were female, 207 (45.4%) were black, and mean age was 52.9±12.3 years. Controlling for potential confounders, the average SLAQ score was significantly higher by 0.3 points [(95% CI 0.1, 0.6); p=0.013] with each unit increase of the n-6:n-3 ratio. Both lupus activity and PROMIS-Sleep Disturbance scores were lower with each 1g/1000 Kcal increase of n-3 fatty acids [SLAQ regression coefficient β=−0.8 (95% CI −1.6, 0.0), p=0.055; PROMIS-Sleep β=−1.1 (95% CI −2.0, −0.2), p=0.017]. Higher n-3 intakes were non-significantly associated with lower levels of depressive symptoms and comorbid fibromyalgia, and higher quality of life, whereas results for the n6:n3 ratio trended in the opposite direction.

Conclusion:

This population-based study suggests that higher dietary intake of n-3 fatty acids, and lower n-6:n-3 ratios, are favorably associated with patient-reported outcomes in SLE, particularly self-reported lupus activity and sleep quality.


Subject:
[+]
Adult
Aged
Cohort Studies
Diet
Diet Surveys
Fatty Acids, Omega-3
Fatty Acids, Omega-6
Female
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Patient Reported Outcome Measures
Quality Of Life

Source:
Arthritis Care Res (Hoboken). 72(7):874-881
Pubmed ID:
31074595
Pubmed Central ID:
PMC6842394
Document Type:
Journal Article
Funding:
U01 DP003250/DP/NCCDPHP CDC HHSUnited States/ ; K01 ES019909/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; UL1 TR002240/TR/NCATS NIH HHSUnited States/ ; P30 DK020572/DK/NIDDK NIH HHSUnited States/ ; ... More +
U01 DP003250/DP/NCCDPHP CDC HHSUnited States/ ; K01 ES019909/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; UL1 TR002240/TR/NCATS NIH HHSUnited States/ ; P30 DK020572/DK/NIDDK NIH HHSUnited States/ ; U01 DP006265/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP001441/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP006489/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR024986/RR/NCRR NIH HHSUnited States/ Less -
Place as Subject:
Michigan
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f709ff690fd61389f989846268da6d70d81116825e5ae59b6897aa0ba03a8428
File Type:

Supporting Files

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