Cost-related prescription non-adherence and patient-reported outcomes in systemic lupus erythematosus: The Michigan Lupus Epidemiology & Surveillance (MILES) Program

Details

• Alternative Title:
  Lupus
• Personal Author:
  Minhas, Deeba ; Marder, Wendy ; Hassett, Afton L. ; Zick, Suzanna M. ; Gordon, Caroline ; Harlow, Sioban D. ; Wang, Lu ; Barbour, Kamil E. ; Helmick, Charles G. ; McCune, W. Joseph ; Somers, Emily C.
• Description:
  Objectives:
  
  Medication access and adherence play key roles in determining patient outcomes. We investigated whether cost-related non-adherence (CRNA) to prescription medications was associated with worse patient-reported outcomes in a population-based systemic lupus erythematosus (SLE) cohort.
  
  Methods:
  
  Sociodemographic and prescription data were collected by structured interviews in 2014–2015 from patients meeting SLE criteria in the established Michigan Lupus Epidemiology & Surveillance (MILES) Cohort. We examined the associations between CRNA and potential confounders such as sociodemographics and health insurance coverage, and SLE activity and damage using multivariable linear regression.
  
  Results:
  
  462 SLE participants completed the study visit: 430 (93.1%) female, 208 (45%) Black, and mean age 53.3 years. 100 (21.6%) participants with SLE reported CRNA in the preceding 12 months. After adjusting for covariates, CRNA was associated with both higher levels of current SLE disease activity [SLAQ: β coeff 2.7 (95% CI 1.3, 4.1), p<0.001] and damage [LDIQ β coeff 1.4 (95% CI 0.5, 2.4), p=0.003]. Race, health insurance status, and fulfilling Fibromyalgia (FM) Survey Criteria were independently associated with both higher (worse) SLAQ and LDIQ scores; female sex was further associated with higher SLAQ scores.
  
  Conclusion:
  
  Patients with SLE who reported CRNA in the previous 12 months had significantly worse self-reported current disease activity and damage scores compared to those not reporting CRNA. Raising awareness and addressing barriers or concerns related to financial implications and accessibility issues in care plans may help to improve these outcomes.
  
  
• Keywords:
  Epidemiology Female Health Services Research Humans Lupus Lupus Erythematosus, Systemic Male Michigan Middle Aged Non-adherence Patient-reported Outcomes Patient Reported Outcome Measures Prescriptions RNA, Complementary

  More +
• Source:
  Lupus. 32(9):1075-1083
• Pubmed ID:
  37378450
• Pubmed Central ID:
  PMC10585710
• Document Type:
  Journal Article
• Funding:
  UM1 TR004404/TR/NCATS NIH HHSUnited States/ ; U01 DP003250/DP/NCCDPHP CDC HHSUnited States/ ; K01 ES019909/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; UL1 TR002240/TR/NCATS NIH HHSUnited States/ ; U01 DP006265/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP006489/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  32
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7058eb9e7f8c5dbc80752189e31b6f4dcdb407e72d01ca495407bcebec83ed98
• Download URL:
  https://stacks.cdc.gov/view/cdc/134350/cdc_134350_DS1.pdf
• File Type:
  [PDF - 486.74 KB ]