Clinical and Molecular Epidemiology of Invasive Group B Streptococcus Disease among Infants, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ji, Wenjing ; Liu, Haiying ; Madhi, Shabir A. ; Cunnington, Marianne ; Zhang, Zilu ; Dangor, Ziyaad ; Zhou, Haijian ; Mu, Xiaoping ; Jin, Zhengjiang ; Wang, Aimin ; Qin, Xiaosong ; Gao, Chunyan ; Zhu, Yuning ; Feng, Xiaodan ; She, Shangyang ; Yang, Shuhua ; Liu, Jing ; Lei, Jine ; Jiang, Lan ; Liu, Zeshi ; Li, Gang ; Li, Qiuhong ; Deng, Qiulian ; Gao, Kankan ; Fang, Yu
• Description:
  Invasive group B Streptococcus (GBS) remains a leading cause of illness and death among infants globally. We conducted prospective and retrospective laboratory-based surveillance of GBS-positive cultures from infants <3 months of age in 18 hospitals across China during January 1, 2015-December 31, 2017. The overall incidence of GBS was 0.31 (95% CI 0.27-0.36) cases/1,000 live births; incidence was 0-0.76 cases/1,000 live births across participating hospitals. The case-fatality rate was 2.3%. We estimated 13,604 cases of GBS and 1,142 GBS-associated deaths in infants <90 days of age annually in China. GBS isolates were most commonly serotype III (61.5%) and clonal complex 17 (40.6%). Enhanced active surveillance and implementation of preventive strategies, such as maternal GBS vaccination, warrants further investigation in China to help prevent these infections.
• Subjects:
  Age Of Onset Child, Preschool Geography, Medical Humans Incidence Infant Infant, Newborn Molecular Epidemiology Molecular Typing Public Health Surveillance Serotyping Streptococcal Infections Streptococcus Agalactiae

  More +
• Source:
  Emerg Infect Dis. 25(11):2021-2030
• Pubmed ID:
  31600132
• Pubmed Central ID:
  PMC6810193
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  25
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b6dd69b7f53b1804979a7b07aa69c2df2e648c4636520d3875f70235b48b20bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/82986/cdc_82986_DS1.pdf
• File Type:
  [PDF - 1.87 MB ]