Comparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016

Garner, Emily; Brown, Connor L.; Schwake, David Otto; Rhoads, William J.; Arango-Argoty, Gustavo; Zhang, Liqing; Jospin, Guillaume; Coil, David A.; Eisen, Jonathan A.; Edwards, Marc A.; Pruden, Amy

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Comparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016

Supporting Files Public Domain

November 2019
By Garner, Emily ; Brown, Connor L. ; Schwake, David Otto ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Garner, Emily ; Brown, Connor L. ; Schwake, David Otto ; Rhoads, William J. ; Arango-Argoty, Gustavo ; Zhang, Liqing ; Jospin, Guillaume ; Coil, David A. ; Eisen, Jonathan A. ; Edwards, Marc A. ; Pruden, Amy
Description:

During the water crisis in Flint, Michigan, USA (2014-2015), 2 outbreaks of Legionnaires' disease occurred in Genesee County, Michigan. We compared whole-genome sequences of 10 clinical Legionella pneumophila isolates submitted to a laboratory in Genesee County during the second outbreak with 103 water isolates collected the following year. We documented a genetically diverse range of L. pneumophila strains across clinical and water isolates. Isolates belonging to 1 clade (3 clinical isolates, 3 water isolates from a Flint hospital, 1 water isolate from a Flint residence, and the reference Paris strain) had a high degree of similarity (2-1,062 single-nucleotide polymorphisms), all L. pneumophila sequence type 1, serogroup 1. Serogroup 6 isolates belonging to sequence type 2518 were widespread in Flint hospital water samples but bore no resemblance to available clinical isolates. L. pneumophila strains in Flint tap water after the outbreaks were diverse and similar to some disease-causing strains.
Subjects:

Drinking Water Genome, Bacterial Humans Legionella Pneumophila Legionnaires' Disease Phylogeny Polymorphism, Single Nucleotide Water Microbiology Whole Genome Sequencing
Source:

Emerg Infect Dis. 25(11):2013-2020
Pubmed ID:

31625848
Pubmed Central ID:

PMC6810188
Document Type:

Journal Article
Place as Subject:

Flint, MI
Volume:

25
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:fc4cc595436a6b2a97bf1221442f866bd93fdd48dd59e9d807643724d9c0553b
Download URL:

https://stacks.cdc.gov/view/cdc/82981/cdc_82981_DS1.pdf
File Type:

[PDF - 1.23 MB ]

File Language:

English

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