Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mishin, Vasiliy P. ; Patel, Mira C. ; Chesnokov, Anton ; De La Cruz, Juan ; Nguyen, Ha T. ; Lollis, Lori ; Hodges, Erin ; Jang, Yunho ; Barnes, John ; Uyeki, Timothy ; Davis, Charles T. ; Wentworth, David E. ; Gubareva, Larisa V.
• Description:
  Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.
• Subjects:
  Animals Antiviral Agents Chickens Dibenzothiepins Dogs Humans Influenza, Human Influenza A Virus Influenza B Virus Influenza In Birds Influenzavirus C Madin Darby Canine Kidney Cells Microbial Sensitivity Tests Morpholines Orthomyxoviridae Infections Oxazines Pyridines Pyridones Swine Swine Diseases Thiepins Thogotovirus Triazines

  More +
• Source:
  Emerg Infect Dis. 25(10):1969-1972
• Pubmed ID:
  31287050
• Pubmed Central ID:
  PMC6759234
• Document Type:
  Journal Article
• Volume:
  25
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e5bf84262f5c5b81b74e9d465edfa5da7c722bbbe83fdf052fd469ec8b765f22
• Download URL:
  https://stacks.cdc.gov/view/cdc/82964/cdc_82964_DS1.pdf
• File Type:
  [PDF - 700.01 KB ]