Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Harvey, Ruth ; Mattiuzzo, Giada ; Hassall, Mark ; Sieberg, Andrea ; Müller, Marcel A. ; Drosten, Christian ; Rigsby, Peter ; Oxenford, Christopher J.
• Corporate Authors:
  study participants
• Description:
  Middle East respiratory syndrome coronavirus (MERS-CoV) was detected in humans in 2012. Since then, sporadic outbreaks with primary transmission through dromedary camels to humans and outbreaks in healthcare settings have shown that MERS-CoV continues to pose a threat to human health. Several serologic assays for MERS-CoV have been developed globally. We describe a collaborative study to investigate the comparability of serologic assays for MERS-CoV and assess any benefit associated with the introduction of a standard reference reagent for MERS-CoV serology. Our study findings indicate that, when possible, laboratories should use a testing algorithm including >2 tests to ensure correct diagnosis of MERS-CoV. We also demonstrate that the use of a reference reagent greatly improves the agreement between assays, enabling more consistent and therefore more meaningful comparisons between results.
• Subjects:
  Antibodies Comparison Of Serologic Assays For Middle East Respiratory Syndrome Coronavirus Diagnostics MERS-CoV Middle East Respiratory Syndrome Coronavirus Research Serology Standard Viruses
• Source:
  Emerg Infect Dis. 25(10):1878-1883
• Pubmed ID:
  31423969
• Pubmed Central ID:
  PMC6759245
• Document Type:
  Journal Article
• Place as Subject:
  Oman ; Republic of Korea ; Saudi Arabia
• Location:
  Asia ; Middle East
• Volume:
  25
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:72d5b756b3ed07962ad2f4e062cd99fbdcff8657ed439b0b3ee9d111886882fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/82962/cdc_82962_DS1.pdf
• File Type:
  [PDF - 816.46 KB ]