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Impact of Intensive Lifestyle Intervention on neural food cue-reactivity: Action for Health in Diabetes Brain Ancillary Study
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May 21 2019
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Source: Obesity (Silver Spring). 27(7):1076-1084
[PDF-344.44 KB]
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Alternative Title:Obesity (Silver Spring)
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Description:Objective:
Look AHEAD was a randomized trial comparing the effects of an intensive lifestyle intervention (ILI) vs. a diabetes support and education (DSE) control group in adults with type 2 diabetes and overweight/obesity. We used functional magnetic resonance imaging (fMRI) to determine if neural food cue-reactivity differed for these groups 10 years after randomization.
Methods:
232 participants (ILI n=125, 72% female, DSE n=107, 64% female) were recruited at 3 Look AHEAD sites for fMRI. Neural response to high-calorie foods compared to non-foods was assessed in DSE vs. ILI. Exploratory correlations were conducted within ILI to identify regions where activity was associated with degree of weight loss.
Results:
Voxel-wise whole-brain comparisons revealed greater reward-processing activity in left caudate in DSE compared to ILI and greater activity in attention/visual processing regions in ILI than DSE (p<0.05, Family Wise Error Corrected). Exploratory analyses revealed greater weight loss among intervention participants from baseline was associated with brain activation indicative of increased attention/visual processing and cognitive control in response to high-calorie food cues (p<0.001, uncorrected).
Conclusions:
These findings suggest there may be legacy effects of participation in a behavioral weight loss intervention, with reduced reward-related activity and enhanced attention/visual processing in response to high-calorie foods.
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Pubmed ID:31112370
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Pubmed Central ID:PMC6591068
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Volume:27
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Issue:7
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