Impact of Intensive Lifestyle Intervention on neural food cue-reactivity: Action for Health in Diabetes Brain Ancillary Study

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  McDermott, Kathryn Demos ; Williams, Samantha E. ; Espeland, Mark A. ; Erickson, Kirk ; Neiberg, Rebecca ; Wadden, Thomas A. ; Bryan, R. Nick ; Desiderio, Lisa ; Leckie, Regina L. ; Falconbridge, Lucy H. ; Jakicic, John M. ; Alonso-Alonso, Miguel ; Wing, Rena R.
• Corporate Authors:
  Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group
• Description:
  Objective:
  
  Look AHEAD was a randomized trial comparing the effects of an intensive lifestyle intervention (ILI) vs. a diabetes support and education (DSE) control group in adults with type 2 diabetes and overweight/obesity. We used functional magnetic resonance imaging (fMRI) to determine if neural food cue-reactivity differed for these groups 10 years after randomization.
  
  Methods:
  
  232 participants (ILI n=125, 72% female, DSE n=107, 64% female) were recruited at 3 Look AHEAD sites for fMRI. Neural response to high-calorie foods compared to non-foods was assessed in DSE vs. ILI. Exploratory correlations were conducted within ILI to identify regions where activity was associated with degree of weight loss.
  
  Results:
  
  Voxel-wise whole-brain comparisons revealed greater reward-processing activity in left caudate in DSE compared to ILI and greater activity in attention/visual processing regions in ILI than DSE (p<0.05, Family Wise Error Corrected). Exploratory analyses revealed greater weight loss among intervention participants from baseline was associated with brain activation indicative of increased attention/visual processing and cognitive control in response to high-calorie food cues (p<0.001, uncorrected).
  
  Conclusions:
  
  These findings suggest there may be legacy effects of participation in a behavioral weight loss intervention, with reduced reward-related activity and enhanced attention/visual processing in response to high-calorie foods.
  
  
• Subjects:
  Article Brain Imaging Intervention Obesity Weight Loss
• Source:
  Obesity (Silver Spring). 27(7):1076-1084
• Pubmed ID:
  31112370
• Pubmed Central ID:
  PMC6591068
• Document Type:
  Journal Article
• Funding:
  U01 DK057151/DK/NIDDK NIH HHS/United States ; U01 DK057135/DK/NIDDK NIH HHS/United States ; UL1 RR024153/RR/NCRR NIH HHS/United States ; P30 DK046204/DK/NIDDK NIH HHS/United States ; Indian Health Service/ ; ULI RR 024153/Clinical Translational Research Center/ ; M01 RR000056/RR/NCRR NIH HHS/United States ; U01 DK057219/DK/NIDDK NIH HHS/United States ; HL/NHLBI NIH HHS/United States ; NR/NINR NIH HHS/United States ; U01 DK057154/DK/NIDDK NIH HHS/United States ; National Center on Minority Health and Health Disparities/ ; DK092237-02S2/DK/NIDDK NIH HHS/United States ; U01 DK056992/DK/NIDDK NIH HHS/United States ; U01 DK057171/DK/NIDDK NIH HHS/United States ; R01 DK092237/DK/NIDDK NIH HHS/United States ; U01 DK057182/DK/NIDDK NIH HHS/United States ; DK092237-01/DK/NIDDK NIH HHS/United States ; U01 DK057136/DK/NIDDK NIH HHS/United States ; U01 DK057002/DK/NIDDK NIH HHS/United States ; U01 DK057177/DK/NIDDK NIH HHS/United States ; U01 DK057078/DK/NIDDK NIH HHS/United States ; M01RR01346/Frederic C. Bartter General Clinical Research Center/ ; U.S. Department of Veterans Affairs/ ; U01 DK057131/DK/NIDDK NIH HHS/United States ; CC/CDC HHS/United States ; Office of Research on Women's Health/ ; M01 RR000043/RR/NCRR NIH HHS/United States ; DK57136, DK57149, DK56990, DK57177, DK57171, DK571/DK/NIDDK NIH HHS/United States ; U01 DK056990/DK/NIDDK NIH HHS/United States ; U01 DK057178/DK/NIDDK NIH HHS/United States ; MO1RR000056/University of Pittsburgh Clinical Research Center/ ; U01 DK057008/DK/NIDDK NIH HHS/United States ; U01 DK057149/DK/NIDDK NIH HHS/United States ; M01 RR001346/RR/NCRR NIH HHS/United States
• Volume:
  27
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8d72170a3cfdb477ee78aa7cacdad56a84cfb18b1daed59dc6e7d28758705e5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/82670/cdc_82670_DS1.pdf
• File Type:
  [PDF - 344.44 KB ]