Sero-identification of the aetiologies of human malaria exposure (Plasmodium spp.) in the Limu Kossa District of Jimma Zone, South western Ethiopia

Details

• Alternative Title:
  Malar J
• Personal Author:
  Feleke, Sindew Mekasha ; Brhane, Bokretsion Gidey ; Mamo, Hassen ; Assefa, Ashenafi ; Woyessa, Adugna ; Ogawa, Guilherme Maerschner ; Cama, Vitaliano
• Description:
  Background
  
  Malaria remains a very important public health problem in Ethiopia. Currently, only Plasmodium falciparum and Plasmodium vivax are considered in the malaria diagnostic and treatment policies. However, the existence and prevalence of Plasmodium ovale spp. and Plasmodium malariae in Ethiopia have not been extensively investigated. The objective of this study was to use a multiplex IgG antibody detection assay to evaluate evidence for exposure to any of these four human malaria parasites among asymptomatic individuals.
  
  Methods
  
  Dried blood spots (DBS) were collected from 180 healthy study participants during a 2016 onchocerciasis survey in the Jimma Zone, southwest Ethiopia. IgG antibody reactivity was detected using a multiplex bead assay for seven Plasmodium antigens: P. falciparum circumsporozoite protein (CSP), P. falciparum apical membrane antigen-1 (AMA1), P. falciparum liver stage antigen-1 (LSA1), and homologs of the merozoite surface protein-1 (MSP1)-19kD antigens that are specific for P. falciparum, P. vivax, P. ovale spp. and P. malariae.
  
  Results
  
  One hundred six participants (59%) were IgG seropositive for at least one of the Plasmodium antigens tested. The most frequent responses were against P. falciparum AMA1 (59, 33%) and P. vivax (55, 28%). However, IgG antibodies against P. ovale spp. and P. malariae were detected in 19 (11%) and 13 (7%) of the participants, respectively, providing serological evidence that P. malariae and P. ovale spp., which are rarely reported, may also be endemic in Jimma.
  
  Conclusion
  
  The findings highlight the informative value of multiplex serology and the need to confirm whether P. malariae and P. ovale spp. are aetiologies of malaria in Ethiopia, which is critical for proper diagnosis and treatment.
  
  
• Subjects:
  Adolescent Adult Aged Antibodies, Protozoan Child Female Humans Immunoglobulin G Malaria Male Middle Aged Plasmodium Malariae Plasmodium Ovale Prevalence Research Seroepidemiologic Studies Young Adult

  More +
• Source:
  Malar J. 18
• Pubmed ID:
  31455373
• Pubmed Central ID:
  PMC6712699
• Document Type:
  Journal Article
• Place as Subject:
  Ethiopia
• Volume:
  18
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:de42464e32ec439f50309961b58d7bafa344f8ecb9d7a98e33f5992680ee6a52
• Download URL:
  https://stacks.cdc.gov/view/cdc/81949/cdc_81949_DS1.pdf
• File Type:
  [PDF - 864.31 KB ]